Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAP | Q12884 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.30 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.30 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13340505 | 0.93 | FAP (0.33) | FAPTSHRMMP2MMP9HDAC4 | |
| SCHEMBL16938890 | 0.90 | FAP (0.32) | FAPTSHRHDAC4HDAC1HDAC6 | |
| SCHEMBL16938907 | 0.90 | FAP (0.32) | FAPTSHRHDAC4HDAC1HDAC6 | |
| SCHEMBL16938902 | 0.88 | HDAC4 (0.32) | FAPTSHRHDAC4HDAC1DDB1 | |
| SCHEMBL16938889 | 0.86 | CTSB (0.40) | FAPHDAC4HDAC1HDAC6 | |
| SCHEMBL13340502 | 0.86 | FAP (0.32) | FAP | |
| SCHEMBL8006962 | 0.82 | DPP4 (0.34) | ADRB3ADRA2BADRA2C | |
| SCHEMBL11975943 | 0.82 | ADRB3 (0.35) | TSHRADRB3ADRA2BADRA2CHDAC4 | |
| SCHEMBL16938908 | 0.81 | TSHR (0.34) | FAPTSHRHDAC4HDAC1HDAC6 | |
| SCHEMBL13082484 | 0.81 | ADRB3 (0.37) | ADRB3ADRA2BADRA2CHDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364310-B1 | 4-AMINO-4-OXOBUTANOYL PEPTIDE CYCLIC ANALOGUES, INHIBITORS OF VIRAL REPLICATION | ACHILLION PHARMACEUTICALS INC (US) | 2015-07-29 | — | — | EP | disclosed |