Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.66 |
| ▸ | NPC1 | O15118 | 7/20 | 0.66 |
| ▸ | RAB9A | P51151 | 7/20 | 0.66 |
| ▸ | POLB | P06746 | 6/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.66 |
| ▸ | HPGD | P15428 | 7/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | TP53 | P04637 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | THRB | P10828 | 1/20 | 0.61 |
| ▸ | UTRN | P46939 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 5/20 | 0.60 |
| ▸ | PPARG | P37231 | 1/20 | 0.60 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.60 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.60 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15569860 | 0.94 | ALDH1A1 (0.70) | SMN1; SMN2ALDH1A1NPC1RAB9APOLB | |
| SCHEMBL2242920 | 0.86 | SMN1; SMN2 (0.80) | SMN1; SMN2ALDH1A1NPC1RAB9APOLB | |
| SCHEMBL2244578 | 0.84 | NPC1 (0.80) | SMN1; SMN2ALDH1A1NPC1RAB9APOLB | |
| SCHEMBL16939847 | 0.83 | SMN1; SMN2 (0.70) | SMN1; SMN2ALDH1A1NPC1RAB9APOLB | |
| SCHEMBL16939851 | 0.83 | SMN1; SMN2 (0.70) | SMN1; SMN2ALDH1A1NPC1RAB9APOLB | |
| SCHEMBL16939853 | 0.83 | SMN1; SMN2 (0.70) | SMN1; SMN2ALDH1A1NPC1RAB9APOLB | |
| SCHEMBL22043476 | 0.81 | SMN1; SMN2 (0.58) | SMN1; SMN2ALDH1A1NPC1RAB9APOLB | |
| SCHEMBL2246316 | 0.81 | ALDH1A1 (0.87) | SMN1; SMN2ALDH1A1NPC1RAB9APOLB | |
| SCHEMBL2607558 | 0.80 | MAPT (0.70) | SMN1; SMN2ALDH1A1NPC1RAB9APOLB | |
| SCHEMBL22043468 | 0.80 | MAPT (0.69) | SMN1; SMN2ALDH1A1NPC1RAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9447134-B2 | Compounds and methods for treating mammalian gastrointestinal microbial infections | BRANDEIS UNIVERSITY (US) | 2016-09-20 | — | — | US | disclosed |
| US-20150210727-A1 | COMPOUNDS AND METHODS FOR TREATING MAMMALIAN GASTROINTESTINAL MICROBIAL INFECTIONS | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2015-07-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150210727-A1 | COMPOUNDS AND METHODS FOR TREATING MAMMALIAN GASTROINTESTINAL MICROBIAL INFECTIONS | IMPDH1, IMPDH2, IMPA1 | SMN1; SMN2 4091/4885ALDH1A1 57/4885NPC1 594/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.