Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Styrene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.67 |
| ▸ | TSHR | P16473 | 3/20 | 0.67 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.60 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.60 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.60 |
| ▸ | TNKS | O95271 | 1/20 | 0.60 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.60 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.60 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.60 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.60 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.60 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | PLIN1 | O60240 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Styrene SCHEMBL6344549 | 1.00 | ALDH1A1 (0.67) | ALDH1A1TSHRHDAC3HDAC4HDAC1 | |
| Styrene SCHEMBL122075 | 1.00 | ALDH1A1 (0.67) | ALDH1A1TSHRHDAC3HDAC4HDAC1 | |
| Styrene SCHEMBL122074 | 1.00 | ALDH1A1 (0.67) | ALDH1A1TSHRHDAC3HDAC4HDAC1 | |
| Styrene SCHEMBL8938902 | 1.00 | ALDH1A1 (0.67) | ALDH1A1TSHRHDAC3HDAC4HDAC1 | |
| Styrene SCHEMBL8348915 | 0.98 | ALDH1A1 (0.64) | ALDH1A1TSHRHDAC3HDAC4HDAC1 | |
| Styrene SCHEMBL8092803 | 0.98 | ALDH1A1 (0.64) | ALDH1A1TSHRHDAC3HDAC4HDAC1 | |
| Styrene SCHEMBL4349561 | 0.98 | ALDH1A1 (0.64) | ALDH1A1TSHRHDAC3HDAC4HDAC1 | |
| Styrene SCHEMBL4983182 | 0.98 | ALDH1A1 (0.64) | ALDH1A1TSHRHDAC3HDAC4HDAC1 | |
| Styrene SCHEMBL17786137 | 0.98 | ALDH1A1 (0.64) | ALDH1A1TSHRHDAC3HDAC4HDAC1 | |
| Styrene SCHEMBL8406802 | 0.98 | ALDH1A1 (0.64) | ALDH1A1TSHRHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117946792-A | Hydraulic oil composition and preparation method thereof | 中国石油化工股份有限公司 | 2024-04-30 | — | — | CN | claimed |
| CN-102041143-B | Two-film lubricating oil | BEIJING ALLUBE PETROCHEM CO LTD | 2013-12-18 | — | — | CN | claimed |
| CN-102199480-B | Method for preparing lubricating agent by utilizing palm liquid oil | UNIV HENAN TECHNOLOGY | 2013-05-01 | — | — | CN | claimed |
| CN-102952617-A | Hydraulic-transmission-braking three-use lubricating oil composition | BEIJING ALLUBE PETROCHEM CO LTD | 2013-03-06 | — | — | CN | claimed |
| CN-102199480-A | Method for preparing lubricating agent by utilizing palm liquid oil | UNIV HENAN TECHNOLOGY | 2011-09-28 | — | — | CN | claimed |
| CN-102041143-A | Two-film lubricating oil | BEIJING ALLUBE PETROCHEM CO LTD | 2011-05-04 | — | — | CN | claimed |
| US-5391452-A | Polyester toner and developer compositions | XEROX CORPORATION (US) | 1995-02-21 | — | — | US | claimed |
| CN-117946792-A | Hydraulic oil composition and preparation method thereof | 中国石油化工股份有限公司 | 2024-04-30 | — | — | CN | disclosed |
| WO-2022220042-A1 | METHOD FOR PURIFYING PROTEIN DERIVED FROM MEMBRANE PROTEIN COMPLEX | 住友ゴム工業株式会社 | 2022-10-20 | — | — | WO | disclosed |
| EP-1731557-B1 | METHOD OF DECOMPOSING PLASTIC | PANASONIC CORP (JP) | 2014-07-09 | — | — | EP | disclosed |
| CN-102041143-B | Two-film lubricating oil | BEIJING ALLUBE PETROCHEM CO LTD | 2013-12-18 | — | — | CN | disclosed |
| CN-102199480-B | Method for preparing lubricating agent by utilizing palm liquid oil | UNIV HENAN TECHNOLOGY | 2013-05-01 | — | — | CN | disclosed |
| CN-102952617-A | Hydraulic-transmission-braking three-use lubricating oil composition | BEIJING ALLUBE PETROCHEM CO LTD | 2013-03-06 | — | — | CN | disclosed |
| EP-1731557-A1 | METHOD OF DECOMPOSING PLASTIC | Matsushita Electric Works, Ltd. (JP) | 2006-12-13 | — | — | EP | disclosed |
| US-5487763-A | DISTILLATE FUEL OIL CONTAINING COPOLYMER OF ALPHA-OLEFIN OR AROMATIC SUBSTITUTED OLEFIN AND SPECIFIED UNSATURATED ESTER TO MODIFY SHAPE AND STRUCTURE OF WAX CRYSTALS, COPOLYMER OF ETHYLENE AND VINYL ACETATE AS POUR POINT DEPRESSANT | EXXON CHEMICAL PATENTS INC. (US) | 1996-01-30 | — | — | US | disclosed |
| EP-0282342-B1 | FUEL COMPOSITIONS | EXXON CHEMICAL PATENTS INC. (US) | 1992-10-14 | — | — | EP | disclosed |
| EP-0183447-B1 | POLYESTERS AS FLOW IMPROVERS FOR HYDROCARBONS | EXXON RESEARCH AND ENGINEERING COMPANY (US) | 1990-03-14 | — | — | EP | disclosed |
| EP-0282342-A1 | Fuel compositions | EXXON CHEMICAL PATENTS INC. (US) | 1988-09-14 | — | — | EP | disclosed |
| EP-0183447-A1 | Polyesters as flow improvers for hydrocarbons | EXXON RESEARCH AND ENGINEERING COMPANY (US) | 1986-06-04 | — | — | EP | disclosed |
| US-3961105-A | PROTECTIVE COATINGS | CERTAIN-TEED PRODUCTS CORPORATION (US) | 1976-06-01 | — | — | US | disclosed |