Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Styrene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.64 |
| ▸ | TSHR | P16473 | 3/20 | 0.64 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.58 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.58 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.58 |
| ▸ | TNKS | O95271 | 1/20 | 0.58 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.58 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.58 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.58 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.58 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.58 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | PLIN1 | O60240 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Styrene SCHEMBL17786137 | 1.00 | ALDH1A1 (0.64) | ALDH1A1TSHRHDAC3HDAC4HDAC1 | |
| Styrene SCHEMBL122075 | 0.98 | ALDH1A1 (0.67) | ALDH1A1TSHRHDAC3HDAC4HDAC1 | |
| Styrene SCHEMBL8938902 | 0.98 | ALDH1A1 (0.67) | ALDH1A1TSHRHDAC3HDAC4HDAC1 | |
| Styrene SCHEMBL122074 | 0.98 | ALDH1A1 (0.67) | ALDH1A1TSHRHDAC3HDAC4HDAC1 | |
| Styrene SCHEMBL1694231 | 0.98 | ALDH1A1 (0.67) | ALDH1A1TSHRHDAC3HDAC4HDAC1 | |
| Styrene SCHEMBL6344549 | 0.98 | ALDH1A1 (0.67) | ALDH1A1TSHRHDAC3HDAC4HDAC1 | |
| Styrene SCHEMBL4349561 | 0.95 | ALDH1A1 (0.64) | ALDH1A1TSHRHDAC3HDAC4HDAC1 | |
| Styrene SCHEMBL4983182 | 0.95 | ALDH1A1 (0.64) | ALDH1A1TSHRHDAC3HDAC4HDAC1 | |
| Styrene SCHEMBL8348915 | 0.95 | ALDH1A1 (0.64) | ALDH1A1TSHRHDAC3HDAC4HDAC1 | |
| Styrene SCHEMBL8092803 | 0.95 | ALDH1A1 (0.64) | ALDH1A1TSHRHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150086606-A1 | BIORESORBABLE AND BIOACTIVE THREE-DIMENSIONAL POROUS MATERIAL AND METHOD FOR THE PRODUCTION THEREOF | BIOACTIVE TECNOLOGIA EM POLIMEROS LTDA ME (BR) | 2015-03-26 | — | — | US | claimed |
| CN-109705252-B | System for ionomer production, production method and applications thereof | 中国石油化工股份有限公司 | 2021-02-05 | — | — | CN | disclosed |
| US-20150086606-A1 | BIORESORBABLE AND BIOACTIVE THREE-DIMENSIONAL POROUS MATERIAL AND METHOD FOR THE PRODUCTION THEREOF | BIOACTIVE TECNOLOGIA EM POLIMEROS LTDA ME (BR) | 2015-03-26 | — | — | US | disclosed |
| US-5948155-A | POLYGLYCERIN OR ALKOXYLATED DIGLYCEROL | FUJI XEROX CO., LTD. (JP) | 1999-09-07 | — | — | US | disclosed |
| CN-85108256-A | LIGHT-SENSITIVE SILVER HALIDE PHOTOGRAPHIC MATERIAL | — | 1986-05-10 | — | — | CN | disclosed |