Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.66 |
| ▸ | HPGD | P15428 | 2/20 | 0.66 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.57 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.56 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | PPARG | P37231 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1695939 | 0.87 | KMT2A (0.88) | KMT2AHPGDMEN1ERCC1ERCC4 | |
| SCHEMBL1695771 | 0.83 | KMT2A (0.71) | KMT2AHPGDADAMTS5MEN1ERCC1 | |
| SCHEMBL14900387 | 0.83 | KMT2A (0.71) | KMT2AHPGDMEN1ERCC1ERCC4 | |
| SCHEMBL1695788 | 0.82 | GAA (0.70) | KMT2AHPGDADAMTS5MEN1ALDH1A1 | |
| SCHEMBL3567670 | 0.82 | KMT2A (0.73) | KMT2AHPGDMEN1ERCC1ERCC4 | |
| SCHEMBL5272168 | 0.81 | KMT2A (1.00) | KMT2AHPGDMEN1ERCC1ERCC4 | |
| SCHEMBL15145905 | 0.81 | ALDH1A1 (0.73) | KMT2AHPGDADAMTS5MEN1ALDH1A1 | |
| SCHEMBL21773980 | 0.80 | MAPK14 (0.64) | MAPK14PPARGL3MBTL1LMNA | |
| SCHEMBL14890394 | 0.80 | HPGD (0.55) | KMT2AHPGDADAMTS5MEN1ALDH1A1 | |
| SCHEMBL1696025 | 0.78 | EPHX2 (0.52) | KMT2AHPGDADAMTS5MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130109698-A1 | Small Molecule Inhibitors of Functions of the HIV-1 Matrix Protein | DREXEL UNIVERSITY | 2013-05-02 | — | — | US | claimed |
| US-20130109698-A1 | Small Molecule Inhibitors of Functions of the HIV-1 Matrix Protein | DREXEL UNIVERSITY | 2013-05-02 | — | — | US | disclosed |
| US-20130109698-A1 | Small Molecule Inhibitors of Functions of the HIV-1 Matrix Protein | DREXEL UNIVERSITY | 2013-05-02 | — | — | US | disclosed |
| WO-2011139636-A1 | SMALL MOLECULE INHIBITORS OF FUNCTIONS OF THE HIV-1 MATRIX PROTEIN | PHILADELPHIA HEALTH & EDUCATION CORPORATION (US) | 2011-11-10 | — | — | WO | disclosed |
| WO-2011139636-A1 | SMALL MOLECULE INHIBITORS OF FUNCTIONS OF THE HIV-1 MATRIX PROTEIN | PHILADELPHIA HEALTH & EDUCATION CORPORATION (US) | 2011-11-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130109698-A1 | Small Molecule Inhibitors of Functions of the HIV-1 Matrix Protein | SERPINB1, TIMP3, MIF | KMT2A 3645/4885HPGD 1653/4885ADAMTS5 118/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.