SCHEMBL16961102

SCHEMBL16961102

N#Cc1ccc(C#N)c([CH]O)c1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA2 P00918 4/20 0.38
CA12 O43570 1/20 0.38
CA3 P07451 1/20 0.38
CA6 P23280 1/20 0.38
CA9 Q16790 1/20 0.38
CA14 Q9ULX7 1/20 0.38
IMPDH2 P12268 1/20 0.37
IMPDH1 P20839 1/20 0.37
RAD51 Q06609 1/20 0.36
ENPP2 Q13822 2/20 0.34
MMP3 P08254 1/20 0.34
CYP2A6 P11509 2/20 0.33
ALDH1A1 P00352 2/20 0.33
PIN1 Q13526 1/20 0.33
CA1 P00915 3/20 0.32
MEN1 O00255 1/20 0.32
MAPT P10636 1/20 0.32
KMT2A Q03164 1/20 0.32
DRD2 P14416 2/20 0.32
DRD3 P35462 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5252920 0.83 IMPDH2 (0.39) CA2CA12CA3CA6CA9
SCHEMBL16960777 0.79 IMPDH2 (0.37) CA2CA12CA3CA6CA9
SCHEMBL7195384 0.79 RAD51 (0.40) CA2CA12CA3CA6CA9
SCHEMBL16955082 0.78 MAOB (0.42) CA12CA9ALDH1A1MAPT
SCHEMBL16958095 0.78 VCAM1 (0.44) CYP2A6ALDH1A1MEN1KMT2ATRPV4
SCHEMBL16962133 0.78 FFAR4 (0.38) TRPV4
SCHEMBL16954722 0.78 AR (0.39) CYP2A6ALDH1A1MEN1MAPTKMT2A
SCHEMBL16956501 0.78 P4HB (0.38) CA2CA12CA3CA6CA9
SCHEMBL16951597 0.78 MEN1 (0.42) CA2CA12CA3CA6CA9
SCHEMBL16955145 0.78 TTR (0.42) CA2CA12CA3CA6CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2900645-A1 3-PHENYLISOXAZOLIN DERIVATIVES WITH HERBICIDAL ACTION Bayer CropScience AG (DE) 2015-08-05 EP disclosed