Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.38 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19917704 | 0.87 | TRPA1 (0.50) | TRPA1BACE1SRCMEN1ALDH1A1 | |
| SCHEMBL19917732 | 0.85 | TRPA1 (0.54) | TRPA1BACE1SRCMEN1ALDH1A1 | |
| SCHEMBL19917722 | 0.81 | BACE1 (0.47) | TRPA1BACE1SRCMEN1LMNA | |
| SCHEMBL19917763 | 0.81 | BACE1 (0.52) | TRPA1BACE1MEN1ALDH1A1LMNA | |
| SCHEMBL16894084 | 0.81 | MMP1 (0.53) | TRPA1MEN1ALDH1A1LMNAPOLB | |
| SCHEMBL19917731 | 0.80 | NPC1 (0.43) | TRPA1BACE1MEN1LMNAKMT2A | |
| SCHEMBL19917653 | 0.80 | TRPA1 (0.38) | TRPA1BACE1ALDH1A1NPC1RAB9A | |
| SCHEMBL16964298 | 0.79 | TRPA1 (0.40) | TRPA1SRCMEN1KMT2A | |
| SCHEMBL19917688 | 0.79 | CASR (0.38) | TRPA1ALDH1A1NPC1RAB9A | |
| SCHEMBL19917768 | 0.78 | TRPA1 (0.41) | TRPA1BACE1CHRM3PTPN5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900642-A1 | SUBSTITUTED SULFONAMIDE COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2015-08-05 | — | — | EP | disclosed |