Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | LSS | P48449 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19917653 | 0.91 | TRPA1 (0.38) | NPC1RAB9APTGER1MAPK1BACE1 | |
| SCHEMBL19917763 | 0.91 | BACE1 (0.52) | HPGDMEN1KMT2ALMNAGAA | |
| SCHEMBL19917688 | 0.90 | CASR (0.38) | NPC1RAB9APTGER1MAPK1PPARA | |
| SCHEMBL19917762 | 0.89 | NPC1 (0.46) | NPC1RAB9APTGER1HPGDMEN1 | |
| SCHEMBL19917774 | 0.88 | TRPA1 (0.46) | PTGER1PPARATRPA1 | |
| SCHEMBL19917735 | 0.87 | TRPA1 (0.40) | HPGDMEN1KMT2AGAATRPA1 | |
| SCHEMBL16964298 | 0.81 | TRPA1 (0.40) | MEN1KMT2ATRPA1 | |
| SCHEMBL16964826 | 0.80 | TRPA1 (0.46) | NPC1RAB9AMEN1KMT2ALMNA | |
| SCHEMBL19917704 | 0.79 | TRPA1 (0.50) | NPC1RAB9AMEN1KMT2ALMNA | |
| SCHEMBL19917764 | 0.79 | CASR (0.39) | NPC1RAB9APTGER1HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900642-B1 | SUBSTITUTED SULFONAMIDE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2018-02-28 | — | — | EP | disclosed |