Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | RORC | P51449 | 4/20 | 0.44 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MME | P08473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19917731 | 0.91 | NPC1 (0.43) | BACE1LMNAMEN1KMT2ABACE2 | |
| SCHEMBL19917653 | 0.84 | TRPA1 (0.38) | BACE1ALDH1A1BACE2TRPA1 | |
| SCHEMBL19917688 | 0.83 | CASR (0.38) | ALDH1A1TRPA1 | |
| SCHEMBL19917774 | 0.83 | TRPA1 (0.46) | TRPA1 | |
| SCHEMBL16964298 | 0.81 | TRPA1 (0.40) | MEN1KMT2ATRPA1 | |
| SCHEMBL16964826 | 0.81 | TRPA1 (0.46) | BACE1ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL19917735 | 0.81 | TRPA1 (0.40) | ALDH1A1MEN1KMT2AMAPTPOLB | |
| SCHEMBL16894086 | 0.81 | ALDH1A1 (0.65) | BACE1ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL19917704 | 0.80 | TRPA1 (0.50) | BACE1ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL19917767 | 0.80 | BACE1 (0.54) | BACE1ALDH1A1LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900642-B1 | SUBSTITUTED SULFONAMIDE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2018-02-28 | — | — | EP | disclosed |