Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CFD | P00746 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16894164 | 0.84 | BRD4 (0.45) | SYKTRPA1CYP1A2CYP2C9L3MBTL1 | |
| SCHEMBL18290410 | 0.82 | CARM1 (0.43) | SYKTRPA1CARM1 | |
| SCHEMBL16965183 | 0.81 | SYK (0.45) | SYKTRPA1TSHRPOLBAOC3 | |
| SCHEMBL16894280 | 0.77 | SYK (0.47) | SYKCFDCNR2 | |
| SCHEMBL22501674 | 0.76 | CTSV (0.52) | TSHRAOC3CYP2C19CYP1A2CYP2D6 | |
| SCHEMBL16965275 | 0.74 | AOC3 (0.47) | SYKTSHRAOC3CYP2C19CYP1A2 | |
| SCHEMBL19917661 | 0.74 | TRPA1 (0.43) | SYKGAATRPA1POLBTP53 | |
| SCHEMBL22501881 | 0.73 | AOC3 (0.45) | GAATSHRAOC3CYP2C19CYP1A2 | |
| SCHEMBL30661718 | 0.72 | MLYCD (0.65) | GAACYP2C19CYP1A2CYP2D6L3MBTL1 | |
| SCHEMBL16906662 | 0.72 | SDHB (0.52) | TSHRCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900642-A1 | SUBSTITUTED SULFONAMIDE COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2015-08-05 | — | — | EP | disclosed |