Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INSR | P06213 | 6/20 | 0.52 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.52 |
| ▸ | MET | P08581 | 7/20 | 0.51 |
| ▸ | ULK1 | O75385 | 2/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 5/20 | 0.38 |
| ▸ | BCL6 | P41182 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2915923 | 0.74 | ULK1 (0.49) | INSRALKMETULK1 | |
| SCHEMBL885968 | 0.72 | MET (0.78) | INSRALKMETULK1 | |
| SCHEMBL886296 | 0.72 | MET (0.74) | INSRALKMETULK1 | |
| SCHEMBL19654273 | 0.71 | ULK1 (0.65) | INSRALKMETULK1 | |
| SCHEMBL2061066 | 0.71 | ALK (0.55) | INSRALKMETSCN9A | |
| SCHEMBL16965915 | 0.70 | MET (0.67) | INSRMET | |
| SCHEMBL17545094 | 0.70 | ULK1 (0.75) | ULK1 | |
| SCHEMBL1742623 | 0.70 | JAK1 (0.47) | — | |
| SCHEMBL886397 | 0.69 | MET (0.68) | INSRALKMETULK1 | |
| SCHEMBL886541 | 0.68 | INSR (1.00) | INSRALKMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-B1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON INC (US) | 2015-08-05 | — | — | EP | disclosed |