Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ULK1 | O75385 | 2/20 | 0.49 |
| ▸ | MET | P08581 | 14/20 | 0.48 |
| ▸ | ALK | Q9UM73 | 13/20 | 0.48 |
| ▸ | INSR | P06213 | 4/20 | 0.48 |
| ▸ | CDK7 | P50613 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17545060 | 0.77 | ULK1 (0.50) | ULK1METALKINSRCDK7 | |
| SCHEMBL16965892 | 0.74 | INSR (0.52) | ULK1METALKINSR | |
| SCHEMBL2061818 | 0.74 | MET (0.55) | ULK1METALKINSRCDK7 | |
| SCHEMBL884794 | 0.73 | MET (0.52) | ULK1METALKINSRCDK7 | |
| SCHEMBL16965906 | 0.73 | ULK1 (0.47) | ULK1METALKINSRCDK7 | |
| SCHEMBL886055 | 0.71 | MET (0.65) | ULK1METALKINSRMAPK8 | |
| SCHEMBL2061801 | 0.71 | MET (0.55) | METALKINSRMAP4K1 | |
| SCHEMBL24073484 | 0.71 | MET (0.73) | ULK1METALKINSRMAPK8 | |
| SCHEMBL886296 | 0.70 | MET (0.74) | ULK1METALKINSRMAPK8 | |
| SCHEMBL886482 | 0.70 | MAP4K1 (0.59) | ULK1METALKINSRCDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |