Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.47 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | LDHA | P00338 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30170409 | 0.81 | KDM4E (0.68) | ALDH1A1LMNAKDM4EKMT2ANR4A1 | |
| SCHEMBL7143621 | 0.81 | KDM4E (0.68) | ALDH1A1LMNAKDM4EKMT2ANR4A1 | |
| SCHEMBL29412561 | 0.79 | PARP1 (0.72) | ALDH1A1ALOX12KDM4EKMT2ANR4A1 | |
| SCHEMBL27908511 | 0.79 | ALDH1A1 (0.49) | ALDH1A1LMNAALOX12KDM4EKMT2A | |
| SCHEMBL1032809 | 0.79 | SLC40A1 (0.49) | ALDH1A1LMNAALOX12KDM4EKMT2A | |
| SCHEMBL5319765 | 0.79 | PARP1 (0.72) | ALDH1A1ALOX12KDM4EKMT2ANR4A1 | |
| SCHEMBL28798022 | 0.79 | KDM4E (0.66) | ALDH1A1LMNAKDM4EKMT2AALOX15 | |
| SCHEMBL27283354 | 0.79 | KDM4E (0.66) | ALDH1A1LMNAKDM4EKMT2AALOX15 | |
| SCHEMBL5149194 | 0.78 | PARP1 (0.70) | ALDH1A1ALOX12KDM4EKMT2ANR4A1 | |
| SCHEMBL21816896 | 0.78 | PARP1 (0.70) | ALDH1A1ALOX12KDM4EKMT2ANR4A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2273992-B1 | QUINOLINES AND RELATED ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2016-05-25 | — | — | EP | disclosed |
| WO-2012003145-A2 | THERAPEUTIC AGENTS FOR OCULAR HYPERTENSION | ALLERGAN, INC. (US) | 2012-01-05 | — | — | WO | disclosed |