Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | XDH | P47989 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | BCHE | P06276 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30752038 | 0.98 | NPC1 (0.33) | CYP3A4RAB9ANPC1MAPTCYP1A2 | |
| Hydrochloric Acid SCHEMBL534853 | 0.80 | — | — | |
| Hydrochloric Acid SCHEMBL30102493 | 0.78 | — | — | |
| Hydrochloric Acid SCHEMBL5385230 | 0.78 | — | — | |
| SCHEMBL818966 | 0.78 | — | — | |
| Hydrochloric Acid SCHEMBL1156276 | 0.76 | — | — | |
| Iodide SCHEMBL670623 | 0.76 | — | — | |
| Hydrochloric Acid SCHEMBL1697487 | 0.74 | BCHE (0.35) | RAB9AMAPTCYP1A2CYP2A6XDH | |
| Hydrochloric Acid SCHEMBL14776873 | 0.73 | CYP3A4 (0.41) | CYP3A4MEN1KMT2ABCHEACHE | |
| SCHEMBL2827554 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130158292-A1 | METHOD FOR PRODUCING METHIONINE | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2013-06-20 | — | — | US | disclosed |
| US-20130109884-A1 | PROCESS FOR PRODUCING ALPHA-KETOCARBOXYLIC ACID | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2013-05-02 | — | — | US | disclosed |
| EP-2585427-A1 | PROCESS FOR PRODUCING ALPHA-KETOCARBOXYLIC ACID | Sumitomo Chemical Company Limited (JP) | 2013-05-01 | — | — | EP | disclosed |
| US-20130072713-A1 | METHOD FOR PRODUCING METHIONINE | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2013-03-21 | — | — | US | disclosed |
| WO-2011162404-A1 | PROCESS FOR PRODUCING ALPHA-KETOCARBOXYLIC ACID | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2011-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130158292-A1 | METHOD FOR PRODUCING METHIONINE | MTR, MSMO1, MGMT | ACHE 742/4885CYP3A4 82/4885RAB9A 4454/4885 |
| US-20130072713-A1 | METHOD FOR PRODUCING METHIONINE | MTR, MGMT, BBOX1 | ACHE 773/4885CYP3A4 157/4885RAB9A 3655/4885 |
| US-20130109884-A1 | PROCESS FOR PRODUCING ALPHA-KETOCARBOXYLIC ACID | ALDH18A1, MCCC2, ALDH7A1 | ACHE 4747/4885CYP3A4 199/4885RAB9A 4655/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.