Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.33 |
| ▸ | SNCA | P37840 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8582802 | 0.86 | LMNA (0.36) | SMN1; SMN2SNCA | |
| SCHEMBL8586570 | 0.84 | NOX1 (0.36) | ALDH1A1TP53HSP90AA1CYP3A4THRB | |
| SCHEMBL16974831 | 0.84 | ALDH1A1 (0.33) | ALDH1A1TP53HSP90AA1CYP3A4THRB | |
| SCHEMBL8583996 | 0.82 | SNCA (0.32) | SMN1; SMN2SNCA | |
| SCHEMBL8582658 | 0.81 | HCAR3 (0.47) | ALDH1A1TP53SMN1; SMN2HCAR3RAB9A | |
| SCHEMBL8580002 | 0.81 | SNCA (0.35) | SMN1; SMN2SNCA | |
| SCHEMBL8585602 | 0.78 | CCNC (0.39) | SMN1; SMN2L3MBTL1SNCARAB9A | |
| SCHEMBL8585953 | 0.76 | NOX1 (0.36) | ALDH1A1TP53HSP90AA1CYP3A4THRB | |
| SCHEMBL8585813 | 0.75 | — | — | |
| SCHEMBL8582981 | 0.72 | SNCA (0.33) | SNCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3099304-A1 | NOVEL THERAPEUTICS FOR THE TREATMENT OF GLAUCOMA | Mayo Foundation for Medical Education and Research (US) | 2016-12-07 | — | — | EP | disclosed |
| WO-2015117024-A1 | NOVEL THERAPEUTICS FOR THE TREATMENT OF GLAUCOMA | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2015-08-06 | — | — | WO | disclosed |