Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | SNCA | P37840 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8580002 | 0.89 | SNCA (0.35) | HTTSNCASMN1; SMN2 | |
| SCHEMBL8582555 | 0.83 | ADRA2A (0.38) | ADRA2AADRA2BADRA2C | |
| SCHEMBL8584133 | 0.81 | SNCA (0.48) | HTTADRA2AADRA2BADRA2CSNCA | |
| SCHEMBL16974925 | 0.81 | TRPA1 (0.37) | ADRA2AADRA2BADRA2CGSK3B | |
| SCHEMBL16974889 | 0.78 | ALDH1A1 (0.33) | SNCARAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL8582802 | 0.77 | LMNA (0.36) | HTTSNCASMN1; SMN2 | |
| SCHEMBL8586573 | 0.76 | NOX1 (0.36) | HTTADRA2AADRA2BADRA2CNPC1 | |
| SCHEMBL8582984 | 0.75 | MMP3 (0.33) | ADRA2AADRA2BADRA2CSNCANPC1 | |
| SCHEMBL8583996 | 0.73 | SNCA (0.32) | SNCASMN1; SMN2 | |
| SCHEMBL8584509 | 0.71 | NOX1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906297-A1 | 1,2,4-BENZOTHIADIAZINE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1999-04-07 | — | — | EP | disclosed |
| WO-1997049692-A1 | 1,2,4-BENZOTHIADIAZINE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1997-12-31 | — | — | WO | disclosed |