Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 8/20 | 0.35 |
| ▸ | ACACB | O00763 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | PLK1 | P53350 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15260275 | 0.78 | ABL1 (0.48) | — | |
| SCHEMBL1282433 | 0.69 | KMT2A (0.37) | KMT2AMEN1OPRM1OPRD1OPRK1 | |
| SCHEMBL1292289 | 0.68 | STING1 (0.49) | KMT2AMEN1POLB | |
| SCHEMBL15265867 | 0.62 | KMT2A (0.40) | KMT2AMEN1OPRM1OPRD1 | |
| SCHEMBL7539138 | 0.62 | SMN1; SMN2 (0.48) | KMT2AMEN1TP53 | |
| SCHEMBL7534511 | 0.61 | ALDH1A1 (0.51) | KMT2AMEN1POLBTP53 | |
| SCHEMBL7247636 | 0.61 | DYRK1A (0.51) | — | |
| SCHEMBL6068038 | 0.60 | LMNA (0.49) | KMT2AMEN1TP53 | |
| SCHEMBL1842323 | 0.60 | NPC1 (0.52) | KMT2AMEN1POLBTP53 | |
| SCHEMBL7546022 | 0.60 | MAPT (0.41) | KMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3102203-A2 | ANTIBACTERIAL COMBINATIONS COMPRISING POLYMYXIN | SPERO GYRASE, INC. (US) | 2016-12-14 | — | — | EP | disclosed |
| WO-2015114452-A2 | ANTIBACTERIAL COMPOUNDS | BIOTA EUROPE LTD (GB) | 2015-08-06 | — | — | WO | disclosed |