Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7534511 | 0.82 | ALDH1A1 (0.51) | MAPTKMT2ALMNAEPHX2ALDH1A1 | |
| SCHEMBL7539138 | 0.78 | SMN1; SMN2 (0.48) | MAPTKMT2ALMNAALDH1A1HTT | |
| SCHEMBL7535208 | 0.77 | MAPK1 (0.50) | MAPTKMT2AMITFLMNAHTT | |
| SCHEMBL6068038 | 0.76 | LMNA (0.49) | MAPTKMT2ALMNATP53SMN1; SMN2 | |
| SCHEMBL7545220 | 0.76 | HSD17B10 (0.45) | ALDH1A1 | |
| SCHEMBL7247636 | 0.74 | DYRK1A (0.51) | LMNA | |
| SCHEMBL7534938 | 0.74 | LMNA (0.47) | MAPTKMT2ALMNATP53SMN1; SMN2 | |
| SCHEMBL1842323 | 0.74 | NPC1 (0.52) | MAPTKMT2ALMNAALDH1A1TP53 | |
| SCHEMBL7540147 | 0.74 | KMT2A (0.55) | MAPTKMT2ALMNAALDH1A1HTT | |
| Hydrochloric Acid SCHEMBL1844041 | 0.73 | NPC1 (0.51) | MAPTKMT2AMITFLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1422262-A | 2-benzothiazolyl urea derivatives and their use as protein kinase inhibitors | ABBOTT GMBH & CO KG (DE) | 2003-06-04 | — | — | CN | disclosed |
| EP-1254123-A1 | 2-BENZOTHIAZOLYL UREA DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | Abbott GmbH & Co. KG (DE) | 2002-11-06 | — | — | EP | disclosed |
| WO-2001057008-A1 | 2-BENZOTHIAZOLYL UREA DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | ABBOTT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG & COMPANY KOMMANDITGESELLSCHAFT (DE) | 2001-08-09 | — | — | WO | disclosed |