Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CCR3 | P51677 | 1/20 | 0.33 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26193868 | 0.79 | ACHE (0.47) | HRH3ACHE | |
| SCHEMBL13945588 | 0.79 | LTA4H (0.33) | LTA4H | |
| SCHEMBL10069986 | 0.77 | ALDH1A1 (0.41) | LTA4HGAA | |
| SCHEMBL14452265 | 0.77 | ALDH1A1 (0.41) | LTA4HGAA | |
| SCHEMBL17506035 | 0.75 | ACHE (0.36) | HRH3ACHE | |
| SCHEMBL12445779 | 0.75 | PARP1 (0.36) | HRH3LTA4H | |
| SCHEMBL14148728 | 0.75 | SIGMAR1 (0.44) | HRH3CXCR4 | |
| SCHEMBL12956814 | 0.74 | HRH3 (0.45) | HRH3 | |
| SCHEMBL19048782 | 0.74 | CCR3 (0.32) | ACHECCR3 | |
| SCHEMBL14098133 | 0.73 | ACHE (0.38) | HRH3ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2902030-A1 | Thienotriazolodiazepine compounds for treating neoplasia | Dana-Farber Cancer Institute, Inc. (US) | 2015-08-05 | — | — | EP | disclosed |