2,4-Dinitrophenol

2,4-Dinitrophenol

SCHEMBL16980

O=[N+]([O-])c1cc(O)cc([N+](=O)[O-])c1.O=[N+]([O-])c1ccc(O)c([N+](=O)[O-])c1.O=[N+]([O-])c1ccc([N+](=O)[O-])c(O)c1.O=[N+]([O-])c1cccc(O)c1[N+](=O)[O-].O=[N+]([O-])c1cccc([N+](=O)[O-])c1O

nearest known ligand 0.52

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPR35 Q9HC97 8/20 0.52
ALDH1A1 P00352 4/20 0.52
MAPK1 P28482 3/20 0.52
TSHR P16473 3/20 0.52
HPGD P15428 2/20 0.52
TP53 P04637 1/20 0.52
SMN1; SMN2 Q16637 1/20 0.52
ALOX15 P16050 3/20 0.43
HSD17B10 Q99714 2/20 0.43
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
KDM4E B2RXH2 1/20 0.43
TTR P02766 1/20 0.43
CYP1A2 P05177 1/20 0.43
MAPT P10636 1/20 0.43
CYP2C9 P11712 1/20 0.43
ALOX12 P18054 1/20 0.43
RECQL P46063 1/20 0.43
PMP22 Q01453 1/20 0.43
HIF1A Q16665 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8959273 0.85 GPR35 (0.72) GPR35ALDH1A1MAPK1TSHRHPGD
2,4-Dinitrophenol SCHEMBL7030615 0.85 GPR35 (0.72) GPR35ALDH1A1MAPK1TSHRHPGD
2,4-Dinitrophenol SCHEMBL27991650 0.84 GPR35 (0.70) GPR35ALDH1A1MAPK1TSHRHPGD
2,4-Dinitrophenol SCHEMBL3799153 0.84 GPR35 (0.36) GPR35ALDH1A1MAPK1TSHRHPGD
Trinitrophenol SCHEMBL9314438 0.83 GPR35 (0.68) GPR35ALDH1A1MAPK1TSHRHPGD
Trinitrophenol SCHEMBL10727440 0.81 GPR35 (0.74) GPR35ALDH1A1MAPK1TSHRHPGD
2,4-Dinitrophenol SCHEMBL5866337 0.81 GPR35 (0.79) GPR35ALDH1A1MAPK1TSHRHPGD
Trinitrophenol SCHEMBL23697948 0.75 GPR35 (0.85) GPR35ALDH1A1MAPK1TSHRHPGD
2,4-Dinitrophenol SCHEMBL27905661 0.75 ALDH1A1 (0.85) GPR35ALDH1A1MAPK1TSHRHPGD
Nitrophenolate SCHEMBL9314441 0.74 GPR35 (0.77) GPR35ALDH1A1MAPK1TSHRHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 43491 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4742895-A2 ASCAROSIDES AND INSECTICIDE COMBINATIONS AND METHODS FOR USE Ascribe Bioscience Inc. (US) 2026-05-20 EP claimed
CN-122055148-A Conjugates, compositions and methods for treating influenza 珀杜研究基金会 2026-05-15 CN claimed
US-20260110607-A1 TRANSPORT AND DETECTION OF EXPLOSIVE SAMPLES WITH MINIMIZED FALSE POSITIVES ALTI LLC (US) 2026-04-23 US claimed
US-20260108476-A1 2,4 DNP and Prodrugs Thereof for Treatment of Cancer MITOCHON PHARMACEUTICALS, INC. (US) 2026-04-23 US claimed
US-20260090969-A1 COMPOSITIONS THAT PROTECT CELLS FROM OXIDATIVE AND MITOCHONDRIAL STRESS Nuchido Limited (GB) 2026-04-02 US claimed
US-12590976-B2 Detection method using both fluorescence and chemiluminescence labels ACCESS MEDICAL SYSTEMS, LTD. (US) 2026-03-31 US claimed
US-12570716-B2 Anti-dinitrophenol chimeric antigen receptors SEATTLE CHILDREN'S HOSPITAL (US) 2026-03-10 US claimed
EP-3536340-B1 AUTOLOGOUS CANCER CELL VACCINE KREUTZ FERNANDO THOME (BR) 2026-03-04 EP claimed
US-12559511-B2 Protein proximity assay in formalin fixed paraffin embedded tissue using caged haptens VENTANA MEDICAL SYSTEMS, INC. (US) 2026-02-24 US claimed
EP-4689168-A1 ULTRASENSITIVE MOLECULAR DETECTION VIA HYBRIDIZATION CHAIN REACTION California Institute of Technology (US) 2026-02-11 EP claimed
US-4268361-A IN SYNERGYSTIC COMBINATION WITH 2,4-DINITROPHENOL AND PHOSPHORIC ACID THE B. F. GOODRICH COMPANY (US) 1981-05-19 US claimed
US-4254351-A Metal acetylacetonate latent accelerators for an epoxy-styrene resin system WESTINGHOUSE ELECTRIC CORP. (US) 1981-03-03 US claimed
US-4247481-A RANEY CATALYSTS, HYDROGENATION OF NITRILES MONSANTO COMPANY (US) 1981-01-27 US claimed
US-4185019-A CYCLIZING STYRENE AND FORMALDEHYDE USING ACID CATALYST CHEPREGI ALAN 1980-01-22 US claimed
US-4173593-A Metal acetylacetonate latent accelerators for an epoxy-styrene resin system WESTINGHOUSE ELECTRIC CORP. (US) 1979-11-06 US claimed
EP-0004414-A1 Mixtures of herbicidal pyridyloxyphenoxypropanoic acid derivatives with other herbicides, and processes of killing unwanted plants therewith IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1979-10-03 EP claimed
US-4033829-A Process for inhibiting polymerization of styrene during distillation MONSANTO COMPANY (US) 1977-07-05 US claimed
US-3974196-A Method for disproportionating ethylenically unsaturated compounds having functional ester groups JAPAN SYNTHETIC RUBBER CO., LTD. (JA) 1976-08-10 US claimed
US-3959395-A Recovery of polymerization inhibitor MONSANTO COMPANY (US) 1976-05-25 US claimed
US-3953518-A Process for preparing γ, δ-unsaturated carbonyl compounds HOFFMANN-LA ROCHE INC. (US) 1976-04-27 US claimed