Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | KDM5A | P29375 | 1/20 | 0.58 |
| ▸ | KDM5C | P41229 | 1/20 | 0.58 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 10/20 | 0.56 |
| ▸ | NPC1 | O15118 | 8/20 | 0.56 |
| ▸ | MYC | P01106 | 1/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1849467 | 0.84 | MAPT (0.79) | LMNAMAPTKDM4EHDAC2HDAC8 | |
| SCHEMBL16352053 | 0.81 | RAB9A (0.62) | LMNAMAPTHDAC2HDAC8HDAC6 | |
| SCHEMBL822668 | 0.81 | RAB9A (0.62) | LMNAMAPTHDAC2HDAC8HDAC6 | |
| SCHEMBL3796253 | 0.81 | RAB9A (0.62) | LMNAMAPTHDAC2HDAC8HDAC6 | |
| SCHEMBL7282271 | 0.81 | HDAC2 (0.78) | MAPTKDM4EKDM5AKDM5CKDM5B | |
| SCHEMBL29846373 | 0.80 | HSD17B10 (0.46) | LMNAMAPTKDM4EHDAC2HDAC8 | |
| SCHEMBL12601200 | 0.80 | POLB (0.53) | LMNAMAPTKDM4ERAB9AMYC | |
| SCHEMBL4657235 | 0.78 | MEN1 (0.63) | MAPTKDM4EKDM5AKDM5CKDM5B | |
| SCHEMBL22268780 | 0.78 | TSHR (0.61) | RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL1116010 | 0.78 | KDM6B (0.59) | MAPTKDM4EHDAC8HDAC6HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011160189-A1 | METHOD OF SCREENING FOR INHIBITORS OF sPLA2-IIA | SCOTT KIERAN (AU) | 2011-12-29 | — | — | WO | disclosed |