Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 13/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16325161 | 0.75 | HTR2B (0.38) | NOTUM | |
| SCHEMBL3988944 | 0.67 | LMNA (0.39) | NOTUMALDH1A1KEAP1HSD17B10 | |
| SCHEMBL15905064 | 0.67 | NOTUM (0.41) | NOTUMKEAP1MAP3K5 | |
| SCHEMBL18708315 | 0.67 | LMNA (0.43) | NOTUM | |
| SCHEMBL10120241 | 0.64 | ALDH1A1 (0.51) | NOTUMALDH1A1 | |
| SCHEMBL15091190 | 0.63 | MAP3K5 (0.51) | NOTUMKEAP1MAP3K5 | |
| SCHEMBL3787307 | 0.61 | MAPK8 (0.38) | NOTUM | |
| SCHEMBL28394131 | 0.61 | PRMT6 (0.35) | NOTUMALDH1A1 | |
| SCHEMBL14842192 | 0.61 | NOTUM (0.45) | NOTUMKEAP1 | |
| SCHEMBL14844631 | 0.61 | NOTUM (0.49) | NOTUMKEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588475-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | Gilead Sciences, Inc. (US) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003387-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2012-01-05 | — | — | WO | disclosed |