Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | ADK | P55263 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.33 |
| ▸ | USP7 | Q93009 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.32 |
| ▸ | AKT1 | P31749 | 2/20 | 0.32 |
| ▸ | RET | P07949 | 3/20 | 0.32 |
| ▸ | AHCY | P23526 | 1/20 | 0.32 |
| ▸ | PI4KA | P42356 | 3/20 | 0.32 |
| ▸ | PI4K2B | Q8TCG2 | 3/20 | 0.32 |
| ▸ | PI4K2A | Q9BTU6 | 3/20 | 0.32 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16987138 | 0.92 | ADK (0.40) | HTTADKADORA2APIK3CDRPS6KB1 | |
| SCHEMBL541850 | 0.84 | PDE10A (0.34) | HTTPDE10A | |
| SCHEMBL30981529 | 0.75 | PDE10A (0.38) | PDE10APIK3CD | |
| SCHEMBL2059083 | 0.74 | KMT2A (0.39) | HTTADK | |
| SCHEMBL21542992 | 0.71 | HTT (0.46) | HTTPDE10A | |
| SCHEMBL31618452 | 0.71 | APLNR (0.35) | PIK3CD | |
| SCHEMBL26686534 | 0.69 | USP7 (0.35) | PDE10AUSP7 | |
| SCHEMBL783585 | 0.67 | — | — | |
| SCHEMBL29799474 | 0.67 | — | — | |
| SCHEMBL1440581 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3105224-A1 | PYRIMIDINE IMIDAZOLE AMINES AS MODULATORS OF KINASE ACTIVITY | Merck Patent GmbH (DE) | 2016-12-21 | — | — | EP | disclosed |
| CN-105980375-A | Pyrimidine imidazole amines as modulators of kinase activity | 默克专利有限公司 | 2016-09-28 | — | — | CN | disclosed |
| US-9434714-B2 | Pyrimidine imidazole amines as modulators of kinase activity | MERCK PATENT GMBH (DE) | 2016-09-06 | — | — | US | disclosed |
| WO-2015123174-A1 | PYRIMIDINE IMIDAZOLE AMINES AS MODULATORS OF KINASE ACTIVITY | MERCK PATENT GMBH (DE) | 2015-08-20 | — | — | WO | disclosed |
| US-20150225371-A1 | Novel Pyrimidine Imidazole Amines as Modulators of Kinase Activity | MERCK PATENT GMBH (DE) | 2015-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150225371-A1 | Novel Pyrimidine Imidazole Amines as Modulators of Kinase Activity | TK1, CHEK2, DCK | HTT 4670/4885PDE10A 975/4885ADK 44/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.