Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 3/20 | 0.33 |
| ▸ | HTR2A | P28223 | 3/20 | 0.33 |
| ▸ | EED | O75530 | 2/20 | 0.32 |
| ▸ | SUZ12 | Q15022 | 2/20 | 0.32 |
| ▸ | EZH2 | Q15910 | 2/20 | 0.32 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.32 |
| ▸ | TNF | P01375 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16872219 | 0.98 | DRD2 (0.35) | KDM4EADORA2ADRD2HTR2AEED | |
| SCHEMBL16987349 | 0.87 | KDM4E (0.32) | KDM4EADORA2ADRD2HTR2A | |
| SCHEMBL16871987 | 0.86 | GPR84 (0.38) | KDM4EDRD2HTR2AEEDSUZ12 | |
| SCHEMBL16872113 | 0.86 | KDM4E (0.37) | KDM4EADORA2ADRD2HTR2AGRM2 | |
| SCHEMBL16872161 | 0.82 | DRD2 (0.34) | DRD2HTR2AMCHR1 | |
| SCHEMBL16872134 | 0.81 | DRD2 (0.32) | DRD2HTR2AMCHR1 | |
| SCHEMBL16872316 | 0.80 | DRD2 (0.36) | DRD2HTR2AMCHR1 | |
| SCHEMBL16872000 | 0.79 | ALOX5AP (0.35) | KDM4EDRD2HTR2AGPR84TNF | |
| SCHEMBL16872007 | 0.79 | DRD2 (0.34) | DRD2HTR2AMCHR1 | |
| SCHEMBL16872375 | 0.79 | CHEK1 (0.46) | KDM4EGPR84ALDH1A1PDE10ACHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150225404-A1 | PYRIDINE DERIVATIVE AND MEDICINE | NIPPON SHINYAKU CO., LTD. (JP) | 2015-08-13 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150225404-A1 | PYRIDINE DERIVATIVE AND MEDICINE | TRPV1, TRPV5, TRPM5 | KDM4E 1569/4885ADORA2A 953/4885DRD2 1999/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.