Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.54 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.53 |
| ▸ | PYGL | P06737 | 1/20 | 0.52 |
| ▸ | PYGM | P11217 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | NAMPT | P43490 | 1/20 | 0.49 |
| ▸ | MET | P08581 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | RAF1 | P04049 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15573077 | 0.90 | DDR2 (0.65) | HDAC1HDAC6HDAC11DDR2PYGL | |
| SCHEMBL16990683 | 0.90 | L3MBTL1 (0.62) | DDR2PYGLPYGMALDH1A1L3MBTL1 | |
| SCHEMBL15575329 | 0.89 | KMT2A (0.60) | DDR2ALDH1A1L3MBTL1POLBKMT2A | |
| SCHEMBL15574695 | 0.88 | POLB (0.49) | HDAC1HDAC6HDAC11DDR2PYGL | |
| SCHEMBL15573349 | 0.88 | DDR2 (0.59) | DDR2ALDH1A1L3MBTL1KMT2AGAA | |
| SCHEMBL16990665 | 0.88 | DDR2 (0.69) | DDR2ALDH1A1L3MBTL1POLBKMT2A | |
| SCHEMBL16990613 | 0.87 | GSK3B (0.48) | DDR2PYGLPYGMALDH1A1L3MBTL1 | |
| SCHEMBL16990731 | 0.86 | CACNA1B (0.48) | HDAC1HDAC6DDR2PYGLPYGM | |
| SCHEMBL15574618 | 0.86 | DDR2 (0.55) | DDR2ALDH1A1L3MBTL1KMT2AGAA | |
| SCHEMBL15575211 | 0.85 | ALDH1A1 (0.66) | HDAC1HDAC6HDAC11ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150225369-A1 | DDR2 INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS | MERCK PATENT GMBH (DE) | 2015-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150225369-A1 | DDR2 INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS | DDR2, DDR1, DDRGK1 | HDAC1 2366/4885HDAC6 620/4885HDAC11 2990/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.