Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.63 |
| ▸ | NOTUM | Q6P988 | 8/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MIF | P14174 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | DPP4 | P27487 | 1/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16991710 | 0.85 | NOTUM (0.67) | MAOANOTUML3MBTL1MIFKDM4E | |
| SCHEMBL16991707 | 0.81 | NOTUM (0.71) | NOTUMMIFKDM4EMAPTKCNH2 | |
| SCHEMBL16271175 | 0.75 | MAOA (0.65) | MAOANOTUML3MBTL1MIFDPP4 | |
| SCHEMBL16991711 | 0.74 | NOTUM (0.43) | NOTUML3MBTL1MIFKCNH2 | |
| SCHEMBL30740915 | 0.73 | MAOA (0.63) | MAOANOTUML3MBTL1MIFKDM4E | |
| SCHEMBL16991673 | 0.73 | PSMD10 (0.53) | MAOANOTUML3MBTL1MIFKDM4E | |
| SCHEMBL12238043 | 0.67 | — | — | |
| SCHEMBL15597050 | 0.67 | MAOA (0.55) | MAOANOTUMDPP4P2RX7KCNH2 | |
| SCHEMBL19211257 | 0.66 | RXRA (0.80) | — | |
| SCHEMBL16271180 | 0.66 | MAOA (0.52) | MAOANOTUMMIFDPP4P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9382213-B2 | Heterocyclic and cyclic analogs of propargyl-linked inhibitors of dihydrofolate reductase | PROMILIAD BIOPHARMA INC. (US) | 2016-07-05 | — | — | US | disclosed |
| US-9382213-B2 | Heterocyclic and cyclic analogs of propargyl-linked inhibitors of dihydrofolate reductase | PROMILIAD BIOPHARMA INC. (US) | 2016-07-05 | — | — | US | disclosed |
| US-9382213-B2 | Heterocyclic and cyclic analogs of propargyl-linked inhibitors of dihydrofolate reductase | PROMILIAD BIOPHARMA INC. (US) | 2016-07-05 | — | — | US | disclosed |
| US-20150225353-A1 | Heterocyclic and Cyclic Analogs of Propargyl-Linked Inhibitors of Dihydrofolate Reductase | UNIVERSITY OF CONNECTICUT | 2015-08-13 | — | — | US | disclosed |
| US-20150225353-A1 | Heterocyclic and Cyclic Analogs of Propargyl-Linked Inhibitors of Dihydrofolate Reductase | UNIVERSITY OF CONNECTICUT | 2015-08-13 | — | — | US | disclosed |
| US-20150225353-A1 | Heterocyclic and Cyclic Analogs of Propargyl-Linked Inhibitors of Dihydrofolate Reductase | UNIVERSITY OF CONNECTICUT | 2015-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150225353-A1 | Heterocyclic and Cyclic Analogs of Propargyl-Linked Inhibitors of Dihydrofolate Reductase | DHFR, DPYD, FOLR1 | MAOA 601/4885NOTUM 3665/4885L3MBTL1 1125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.