SCHEMBL16992006

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL18310129	0.90	NPC1 (0.62)	NPC1PKMRAB9AACHEBACE1
	SCHEMBL16991973	0.83	NPC1 (0.55)	NPC1PKMRAB9AACHEBACE1
	SCHEMBL14782977	0.82	HPGD (0.55)	NPC1PKMRAB9AACHEBACE1
	SCHEMBL25720038	0.81	MEN1 (0.55)	NPC1PKMRAB9AACHEBACE1
	SCHEMBL6336112	0.78	ERCC1 (0.69)	NPC1PKMRAB9AACHEBACE1
	SCHEMBL14782827	0.77	ERCC1 (0.53)	NPC1PKMRAB9AALDH1A1SMN1; SMN2
	SCHEMBL3264766	0.77	BDKRB1 (0.53)	NPC1PKMRAB9AALDH1A1SMN1; SMN2
	SCHEMBL4242416	0.77	POLB (0.62)	NPC1RAB9AACHEBACE1ALDH1A1
	SCHEMBL5503225	0.77	PPARG (0.51)	NPC1RAB9AALDH1A1SMN1; SMN2HSD17B10
	SCHEMBL24822576	0.76	ALDH1A1 (0.50)	ALDH1A1POLBHPGDLMNAGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.