Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC1 | P07992 | 1/20 | 0.53 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 6/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14782977 | 0.95 | HPGD (0.55) | ERCC1ERCC4HPGDLMNAALDH1A1 | |
| Hydrochloric Acid SCHEMBL25251752 | 0.88 | HPGD (0.49) | ERCC1ERCC4HPGDLMNAALDH1A1 | |
| SCHEMBL14783181 | 0.86 | ALDH1A1 (0.58) | ERCC1ERCC4HPGDLMNAALDH1A1 | |
| SCHEMBL14782820 | 0.85 | LMNA (0.48) | ERCC1ERCC4HPGDLMNAALDH1A1 | |
| SCHEMBL14782775 | 0.82 | PKM (0.55) | HPGDLMNAALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL30491752 | 0.80 | ERCC1 (0.52) | ERCC1ERCC4HPGDLMNAALDH1A1 | |
| SCHEMBL14782772 | 0.80 | ERCC1 (0.52) | ERCC1ERCC4HPGDLMNAALDH1A1 | |
| SCHEMBL18810198 | 0.77 | ERCC1 (0.49) | ERCC1ERCC4HPGDLMNAALDH1A1 | |
| SCHEMBL16992006 | 0.77 | NPC1 (0.62) | ERCC1ERCC4HPGDLMNAALDH1A1 | |
| SCHEMBL14783152 | 0.77 | LMNA (0.55) | HPGDLMNAALDH1A1SMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013038308-A1 | SUBSTITUTED BICYCLIC HETEROARYL COMPOUNDS AS mPGES-1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2013-03-21 | — | — | WO | disclosed |
| WO-2013038308-A1 | SUBSTITUTED BICYCLIC HETEROARYL COMPOUNDS AS mPGES-1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2013-03-21 | — | — | WO | disclosed |