Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.37 |
| ▸ | PPARG | P37231 | 2/20 | 0.36 |
| ▸ | PPARA | Q07869 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27903964 | 0.85 | GPR84 (0.39) | KCNH2PPARGPPARAMEN1KMT2A | |
| SCHEMBL27903971 | 0.78 | GRM2 (0.34) | PPARGPPARAMEN1KMT2APLA2G2A | |
| SCHEMBL1699348 | 0.78 | PSIP1 (0.39) | CYP3A4LMNASMN1; SMN2 | |
| SCHEMBL1699271 | 0.78 | PSIP1 (0.39) | CYP3A4LMNASMN1; SMN2 | |
| SCHEMBL27903966 | 0.78 | CXCR5 (0.33) | PPARGPPARAMEN1KMT2APLA2G2A | |
| SCHEMBL27921784 | 0.76 | ESR1 (0.41) | KCNH2PPARGPPARACNR2ESR1 | |
| SCHEMBL27921912 | 0.76 | GPR84 (0.41) | KCNH2PPARGPPARAMEN1KMT2A | |
| SCHEMBL27903976 | 0.76 | DHODH (0.37) | PPARGPPARADHODHCNR1 | |
| SCHEMBL1699401 | 0.74 | PTPN1 (0.36) | ALOX5KCNH2PPARGPPARAMEN1 | |
| SCHEMBL27921762 | 0.74 | CTRC (0.39) | PPARGPPARADHODHCYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588450-A1 | NAPHT- 2 -YLACETIC ACID DERIVATIVES TO TREAT AIDS | Gilead Sciences, Inc. (US) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003497-A1 | NAPHT- 2 -YLACETIC ACID DERIVATIVES TO TREAT AIDS | GILEAD SCIENCES, INC. (US) | 2012-01-05 | — | — | WO | disclosed |