Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 7/20 | 0.34 |
| ▸ | PPARD | Q03181 | 7/20 | 0.34 |
| ▸ | PPARA | Q07869 | 7/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 6/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD1 | P21728 | 1/20 | 0.31 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
| ▸ | DRD5 | P21918 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1699571 | 0.80 | PTGDR2 (0.37) | PTGDR2HTR2C | |
| SCHEMBL10272102 | 0.75 | PTGDR2 (0.37) | PPARAPTGDR2SMN1; SMN2TSHRHTR2A | |
| SCHEMBL1699760 | 0.69 | PTGDR2 (0.35) | PPARGPPARDPPARAPTGDR2MMP2 | |
| SCHEMBL1699307 | 0.68 | CYP3A4 (0.45) | PPARGPTGDR2 | |
| SCHEMBL10271593 | 0.67 | CYP3A4 (0.38) | PPARAPTGDR2SMN1; SMN2TSHRHTR2A | |
| SCHEMBL1699408 | 0.67 | CYP19A1 (0.42) | PPARGTSHR | |
| SCHEMBL1699420 | 0.65 | MTNR1B (0.38) | — | |
| SCHEMBL28334586 | 0.64 | SLC6A2 (0.40) | PTGDR2DRD2DRD1DRD4DRD5 | |
| SCHEMBL31204476 | 0.64 | TSHR (0.46) | TSHRHTR2AHTR2CHTR2BEPAS1 | |
| SCHEMBL1701440 | 0.64 | ALDH1A1 (0.42) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588450-A1 | NAPHT- 2 -YLACETIC ACID DERIVATIVES TO TREAT AIDS | Gilead Sciences, Inc. (US) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003497-A1 | NAPHT- 2 -YLACETIC ACID DERIVATIVES TO TREAT AIDS | GILEAD SCIENCES, INC. (US) | 2012-01-05 | — | — | WO | disclosed |