Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8315808 | 0.89 | — | — | |
| SCHEMBL7529018 | 0.84 | RAB9A (0.37) | ALDH1A1HSD17B10CYP2A6TDP1MEN1 | |
| SCHEMBL14291822 | 0.84 | NPC1 (0.32) | TSHRNPC1DHFRTYMS | |
| SCHEMBL8870392 | 0.83 | ALDH1A1 (0.35) | ALDH1A1HSD17B10TSHRCYP2A6TDP1 | |
| Dimethylformamide SCHEMBL5643757 | 0.80 | KDM4E (0.33) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL8681014 | 0.80 | ALDH1A1 (0.39) | ALDH1A1HSD17B10TSHRCYP2A6TDP1 | |
| SCHEMBL9035829 | 0.77 | HTR2C (0.34) | CYP19A1 | |
| SCHEMBL9917550 | 0.77 | HSD17B10 (0.43) | ALDH1A1HSD17B10TSHRCYP2A6TDP1 | |
| SCHEMBL15196167 | 0.77 | ALDH1A1 (0.37) | ALDH1A1HSD17B10TSHRCYP2A6TDP1 | |
| SCHEMBL1972891 | 0.77 | ALDH1A1 (0.37) | ALDH1A1HSD17B10TSHRCYP2A6TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 141 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0945451-B1 | Photochrome diaryl-naphtopyran with at least one aminosubstituted aryl rest | RODENSTOCK OPTIK G (DE) | 2002-12-18 | — | — | EP | claimed |
| EP-0945451-A1 | Photochrome diaryl-naphtopyran with at least one aminosubstituted aryl rest | Optische Werke G. Rodenstock (DE) | 1999-09-29 | — | — | EP | claimed |
| US-20230350115-A1 | DYE MICROENVIRONMENT | HOYA OPTICAL LABS OF AMERICA, INC. (US) | 2023-11-02 | — | — | US | disclosed |
| US-20230350115-A1 | DYE MICROENVIRONMENT | HOYA OPTICAL LABS OF AMERICA, INC. (US) | 2023-11-02 | — | — | US | disclosed |
| US-20230265066-A1 | NAPHTHOPYRAN-CONTAINING COMPOUND, POLYMER, MIXTURE, COMPOSITION AND USE THEREOF IN WATER-SOLUBLE PHOTOCHROMIC MATERIALS | NANO AND ADVANCED MATERIALS INSTITUTE LIMITED (HK) | 2023-08-24 | — | — | US | disclosed |
| US-20230265066-A1 | NAPHTHOPYRAN-CONTAINING COMPOUND, POLYMER, MIXTURE, COMPOSITION AND USE THEREOF IN WATER-SOLUBLE PHOTOCHROMIC MATERIALS | NANO AND ADVANCED MATERIALS INSTITUTE LIMITED (HK) | 2023-08-24 | — | — | US | disclosed |
| US-11733441-B2 | Dye microenvironment | HOYA OPTICAL LABS OF AMERICA, INC. (US) | 2023-08-22 | — | — | US | disclosed |
| US-11733441-B2 | Dye microenvironment | HOYA OPTICAL LABS OF AMERICA, INC. (US) | 2023-08-22 | — | — | US | disclosed |
| US-11560500-B2 | Optical adhesive and optical laminates and lenses formed with same | HOYA OPTICAL LABS OF AMERICA, INC. (US) | 2023-01-24 | — | — | US | disclosed |
| US-11427754-B2 | Photochromic polyurethane laminate | HOYA OPTICAL LABS OF AMERICA, INC. (US) | 2022-08-30 | — | — | US | disclosed |
| CN-113943267-A | Method for synthesizing naphthopyran photochromic dye by using microchannel reactor | 广州盛色科技有限公司 | 2022-01-18 | — | — | CN | disclosed |
| EP-0613475-A1 | PHOTOCHROMIC NAPHTHOPYRAN COMPOUNDS | PPG INDUSTRIES, INC. (US) | 1994-09-07 | — | — | EP | disclosed |
| US-5340857-A | Ophthalmic lenses, plastic transparencies | PPG INDUSTRIES, INC. (US) | 1994-08-23 | — | — | US | disclosed |
| WO-1994007889-A1 | PHOTOCHROMIC NAPHTHOPYRAN COMPOUNDS | PPG INDUSTRIES, INC. (US) | 1994-04-14 | — | — | WO | disclosed |
| US-5274132-A | Photochromic naphthopyran compounds | TRANSITIONS OPTICAL, INC. (US) | 1993-12-28 | — | — | US | disclosed |
| EP-0560898-A4 | PHOTOCHROMIC NAPHTHOPYRANS | — | 1993-11-18 | — | — | EP | disclosed |
| EP-0560898-A1 | PHOTOCHROMIC NAPHTHOPYRANS. | PPG INDUSTRIES INC (US) | 1993-09-22 | — | — | EP | disclosed |
| WO-1993010112-A1 | PHOTOCHROMIC NAPHTHOPYRAN COMPOUNDS | PPG INDUSTRIES, INC. (US) | 1993-05-27 | — | — | WO | disclosed |
| WO-1992009593-A1 | PHOTOCHROMIC NAPHTHOPYRANS | PPG INDUSTRIES, INC. (US) | 1992-06-11 | — | — | WO | disclosed |
| US-5066818-A | Lenses, plastic transparencies | PPG INDUSTRIES, INC. (US) | 1991-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230265066-A1 | NAPHTHOPYRAN-CONTAINING COMPOUND, POLYMER, MIXTURE, COMPOSITION AND USE THEREOF IN WATER-SOLUBLE PHOTOCHROMIC MATERIALS | TYR, PWWP2B, GANC | ALDH1A1 3291/4885HSD17B10 3274/4885TSHR 4295/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.