Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 8/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | MMP1 | P03956 | 1/20 | 0.49 |
| ▸ | MMP9 | P14780 | 1/20 | 0.49 |
| ▸ | MMP13 | P45452 | 1/20 | 0.49 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14962728 | 0.92 | CYP2D6 (0.53) | CYP2D6ALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL14962729 | 0.92 | CYP2D6 (0.53) | CYP2D6ALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL14677254 | 0.92 | CYP2D6 (0.53) | CYP2D6ALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL1290759 | 0.86 | CYP3A4 (0.65) | CYP2D6ALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL3498095 | 0.84 | CYP2D6 (0.56) | CYP2D6ALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL14081425 | 0.84 | CYP2D6 (0.56) | CYP2D6ALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL3510474 | 0.83 | CYP2D6 (0.55) | CYP2D6ALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL6746046 | 0.82 | KDM4E (0.60) | CYP2D6ALDH1A1OPRL1POLB | |
| SCHEMBL21287577 | 0.82 | KMT2A (0.57) | CYP2D6ALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL18203100 | 0.82 | L3MBTL1 (0.63) | CYP2D6ALDH1A1MEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9249098-B2 | Derivatives of donepezil | CHENG XUEHENG (US) | 2016-02-02 | — | — | US | disclosed |
| US-9249098-B2 | Derivatives of donepezil | CHENG XUEHENG (US) | 2016-02-02 | — | — | US | disclosed |
| US-20150225343-A1 | NOVEL DERIVATIVES OF DONEPEZIL | CHENG XUEHENG (US) | 2015-08-13 | — | — | US | disclosed |
| US-20150225343-A1 | NOVEL DERIVATIVES OF DONEPEZIL | CHENG XUEHENG (US) | 2015-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150225343-A1 | NOVEL DERIVATIVES OF DONEPEZIL | ACHE, BCHE, HNMT | CYP2D6 487/4885ALDH1A1 324/4885CYP3A4 533/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.