Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 6/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 3/20 | 0.31 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17004358 | 0.80 | CHRNA7 (0.56) | CHRNA7KCNH2CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL3833132 | 0.80 | MGAM (0.39) | CHRNA7CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL17004237 | 0.80 | CHRNB2 (0.39) | CHRNA7CHRNB2CHRNB4CHRNA3CHRNA4 | |
| Abt-126 SCHEMBL16033886 | 0.80 | CHRNB2 (0.49) | CHRNA7CHRNB2CHRNB4CHRNA3CHRNA4 | |
| Abt-126 SCHEMBL878680 | 0.80 | CHRNB2 (0.49) | CHRNA7CHRNB2CHRNB4CHRNA3CHRNA4 | |
| Abt-126 SCHEMBL16782423 | 0.80 | CHRNB2 (0.49) | CHRNA7CHRNB2CHRNB4CHRNA3CHRNA4 | |
| Abt-126 SCHEMBL12695541 | 0.80 | CHRNB2 (0.49) | CHRNA7CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL17004229 | 0.79 | CHRNA7 (0.48) | CHRNA7KCNH2CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL17004231 | 0.79 | CHRNA7 (0.49) | CHRNA7KCNH2CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL17004239 | 0.78 | CHRNA7 (0.47) | CHRNA7KCNH2CHRNB2CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099795-B1 | AZAADAMANTANE DERIVATIVES AND THEIR USES AS NICOTINIC ACETYLCHOLINE RECEPTORS LIGANDS | ABBVIE BAHAMAS LTD (BS) | 2015-08-19 | — | — | EP | disclosed |