Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 6/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 5/20 | 0.34 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 5/20 | 0.33 |
| ▸ | WNT1 | P04628 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17004229 | 0.84 | CHRNA7 (0.48) | CHRNA7KCNH2KDM1ADYRK1ACHRNB2 | |
| SCHEMBL17004292 | 0.79 | MAOB (0.33) | CHRNA7KCNH2CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL17004212 | 0.79 | CHRNA7 (0.56) | CHRNA7KCNH2DYRK1ACHRNB2CHRNB4 | |
| SCHEMBL17004265 | 0.78 | FAAH (0.40) | CHRNA7KCNH2CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL17004202 | 0.78 | CHRNA7 (0.38) | CHRNA7KCNH2KDM1ADYRK1ACHRNB2 | |
| SCHEMBL17004220 | 0.77 | CHRNB2 (0.36) | CHRNA7DYRK1ACHRNB2CHRNB4CHRNA3 | |
| SCHEMBL17004293 | 0.77 | CHRNB2 (0.34) | CHRNA7CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL3622692 | 0.76 | CHRNA7 (0.44) | CHRNA7KCNH2KDM1ADYRK1ACHRNB2 | |
| SCHEMBL3622695 | 0.76 | CHRNA7 (0.44) | CHRNA7KCNH2KDM1ADYRK1ACHRNB2 | |
| SCHEMBL17004269 | 0.75 | CHRNB2 (0.35) | CHRNA7KCNH2CHRNB2CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099795-B1 | AZAADAMANTANE DERIVATIVES AND THEIR USES AS NICOTINIC ACETYLCHOLINE RECEPTORS LIGANDS | ABBVIE BAHAMAS LTD (BS) | 2015-08-19 | — | — | EP | disclosed |