Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 13/20 | 0.56 |
| ▸ | CHRNB2 | P17787 | 7/20 | 0.56 |
| ▸ | CHRNA4 | P43681 | 7/20 | 0.56 |
| ▸ | CHRNB4 | P30926 | 6/20 | 0.56 |
| ▸ | CHRNA3 | P32297 | 6/20 | 0.56 |
| ▸ | GUSB | P08236 | 6/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17004231 | 0.93 | CHRNA7 (0.49) | CHRNA7CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL17004194 | 0.83 | CHRNA7 (0.42) | CHRNA7CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL17004202 | 0.80 | CHRNA7 (0.38) | CHRNA7CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL17004207 | 0.79 | CHRNA7 (0.64) | CHRNA7CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL3833132 | 0.79 | MGAM (0.39) | CHRNA7CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL17004237 | 0.79 | CHRNB2 (0.39) | CHRNA7CHRNB2CHRNA4CHRNB4CHRNA3 | |
| Abt-126 SCHEMBL16033886 | 0.79 | CHRNB2 (0.49) | CHRNA7CHRNB2CHRNA4CHRNB4CHRNA3 | |
| Abt-126 SCHEMBL16782423 | 0.79 | CHRNB2 (0.49) | CHRNA7CHRNB2CHRNA4CHRNB4CHRNA3 | |
| Abt-126 SCHEMBL878680 | 0.79 | CHRNB2 (0.49) | CHRNA7CHRNB2CHRNA4CHRNB4CHRNA3 | |
| Abt-126 SCHEMBL12695541 | 0.79 | CHRNB2 (0.49) | CHRNA7CHRNB2CHRNA4CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099795-B1 | AZAADAMANTANE DERIVATIVES AND THEIR USES AS NICOTINIC ACETYLCHOLINE RECEPTORS LIGANDS | ABBVIE BAHAMAS LTD (BS) | 2015-08-19 | — | — | EP | disclosed |