Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Fenspiride. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.97 |
| ▸ | LMNA | P02545 | 1/20 | 0.97 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.97 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.97 |
| ▸ | TSHR | P16473 | 1/20 | 0.97 |
| ▸ | DRD1 | P21728 | 1/20 | 0.97 |
| ▸ | MAPT | P10636 | 1/20 | 0.95 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.95 |
| ▸ | SIGMAR1 | Q99720 | 15/20 | 0.58 |
| ▸ | OPRM1 | P35372 | 10/20 | 0.58 |
| ▸ | DRD2 | P14416 | 4/20 | 0.56 |
| ▸ | HTR2A | P28223 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fenspiride SCHEMBL21016 | 0.99 | LMNA (1.00) | LMNACHRM2ADRA2ACYP2D6TSHR | |
| Fenspiride SCHEMBL613462 | 0.97 | MAPT (1.00) | LMNACHRM2ADRA2ACYP2D6TSHR | |
| Fenspiride SCHEMBL9223216 | 0.97 | LMNA (0.97) | LMNACHRM2ADRA2ACYP2D6TSHR | |
| SCHEMBL9068521 | 0.85 | LMNA (0.75) | LMNACHRM2ADRA2ACYP2D6TSHR | |
| SCHEMBL2604320 | 0.85 | TSHR (0.75) | LMNACHRM2ADRA2ACYP2D6TSHR | |
| SCHEMBL11285193 | 0.82 | LMNA (0.70) | LMNACHRM2ADRA2ACYP2D6TSHR | |
| Hydrochloric Acid SCHEMBL11284963 | 0.81 | MAPT (0.71) | LMNACHRM2ADRA2ACYP2D6TSHR | |
| SCHEMBL17317198 | 0.81 | LMNA (0.69) | LMNACHRM2ADRA2ACYP2D6TSHR | |
| Fenspiride SCHEMBL6671915 | 0.81 | LMNA (0.67) | LMNACHRM2ADRA2ACYP2D6TSHR | |
| SCHEMBL17101331 | 0.80 | TSHR (0.68) | LMNACHRM2ADRA2ACYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230082555-A1 | Composition for Medium | KATAOKA CORPORATION (JP) | 2023-03-16 | — | — | US | disclosed |
| EP-4083194-A1 | COMPOSITION FOR MEDIUM | Kataoka Corporation (JP) | 2022-11-02 | — | — | EP | disclosed |
| CN-114729312-A | Composition for culture medium | 株式会社片冈制作所 | 2022-07-08 | — | — | CN | disclosed |
| WO-2021106698-A1 | COMPOSITION FOR MEDIUM | 株式会社片岡製作所 | 2021-06-03 | — | — | WO | disclosed |
| EP-3482753-B1 | COMPOSITIONS AND THEIR USES FOR THE TREATMENT OF DIABETES AND RELATED CONDITIONS BY CONTROLLING BLOOD GLUCOSE LEVEL | PHARNEXT (FR) | 2021-01-27 | — | — | EP | disclosed |
| US-20200222409-A1 | COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETES AND RELATED CONDITIONS BY CONTROLLING BLOOD GLUCOSE LEVEL | PHARNEXT (FR) | 2020-07-16 | — | — | US | disclosed |
| US-10617689-B2 | Compositions, methods and uses for the treatment of diabetes and related conditions by controlling blood glucose level | PHARNEXT (FR) | 2020-04-14 | — | — | US | disclosed |
| US-10596160-B2 | Compositions, methods and uses for the treatment of diabetes and related conditions by controlling blood glucose level | PHARNEXT (FR) | 2020-03-24 | — | — | US | disclosed |
| EP-2914252-B1 | COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETES AND RELATED CONDITIONS BY CONTROLLING BLOOD GLUCOSE LEVEL | PHARNEXT (FR) | 2019-09-04 | — | — | EP | disclosed |
| EP-3482753-A1 | COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETES AND RELATED CONDITIONS BY CONTROLLING BLOOD GLUCOSE LEVEL | Pharnext (FR) | 2019-05-15 | — | — | EP | disclosed |
| US-20190008841-A1 | COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETES AND RELATED CONDITIONS BY CONTROLLING BLOOD GLUCOSE LEVEL | PHARNEXT (FR) | 2019-01-10 | — | — | US | disclosed |
| US-10092554-B2 | Compositions, methods and uses for the treatment of diabetes and related conditions by controlling blood glucose level | PHARNEXT (FR) | 2018-10-09 | — | — | US | disclosed |
| EP-3137065-A2 | COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETIC NEUROPATHIES | Pharnext (FR) | 2017-03-08 | — | — | EP | disclosed |
| US-20170049777-A1 | COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETIC NEUROPATHIES | PHARNEXT (FR) | 2017-02-23 | — | — | US | disclosed |
| US-20160235693-A1 | COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETES AND RELATED CONDITIONS BY CONTROLLING BLOOD GLUCOSE LEVEL | PHARNEXT (FR) | 2016-08-18 | — | — | US | disclosed |
| WO-2015165948-A2 | COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETIC NEUROPATHIES | PHARNEXT (FR) | 2015-11-05 | — | — | WO | disclosed |
| US-20150231123-A1 | COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETES AND RELATED CONDITIONS BY CONTROLLING BLOOD GLUCOSE LEVEL | PHARNEXT (FR) | 2015-08-20 | — | — | US | disclosed |