Fenspiride

Fenspiride

SCHEMBL613462

Cl.O=C1NCC2(CCN(CCc3ccccc3)CC2)O1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Fenspiride. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CHRM2 known ✓ P08172 1/20 0.97
ADRA2A known ✓ P08913 1/20 0.97
DRD1 known ✓ P21728 1/20 0.97
SIGMAR1 known ✓ Q99720 14/20 0.59
DRD2 known ✓ P14416 5/20 0.59
OPRM1 known ✓ P35372 9/20 0.58
HTR2A known ✓ P28223 1/20 0.55
KCNH2 known ✓ Q12809 3/20 0.54
MAPT P10636 1/20 1.00
KMT2A Q03164 1/20 1.00
LMNA P02545 1/20 0.97
CYP2D6 P10635 1/20 0.97
TSHR P16473 1/20 0.97

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fenspiride SCHEMBL21016 0.99 LMNA (1.00) MAPTKMT2ALMNACHRM2ADRA2A
Fenspiride SCHEMBL9223216 0.97 LMNA (0.97) MAPTKMT2ALMNACHRM2ADRA2A
Fenspiride SCHEMBL17006239 0.97 LMNA (0.97) MAPTKMT2ALMNACHRM2ADRA2A
SCHEMBL9068521 0.85 LMNA (0.75) MAPTKMT2ALMNACHRM2ADRA2A
SCHEMBL2604320 0.85 TSHR (0.75) MAPTKMT2ALMNACHRM2ADRA2A
Hydrochloric Acid SCHEMBL11284963 0.83 MAPT (0.71) MAPTKMT2ALMNACHRM2ADRA2A
SCHEMBL11285193 0.82 LMNA (0.70) MAPTKMT2ALMNACHRM2ADRA2A
SCHEMBL17317198 0.81 LMNA (0.69) MAPTKMT2ALMNACHRM2ADRA2A
Fenspiride SCHEMBL6671915 0.81 LMNA (0.67) MAPTKMT2ALMNACHRM2ADRA2A
SCHEMBL17101331 0.80 TSHR (0.68) MAPTKMT2ALMNACHRM2ADRA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 549 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025133679-A1 COMPOUNDS AND COMPOSITION FOR DNA PROTECTION ASSOCIAÇÃO PARA DESENVOLVIMENTO DO CENTRO ACADÉMICO DE INVESTIGAÇÃO E FORMAÇÃO BIOMÉDICA DO ALGARVE, AD-ABC (PT) 2025-06-26 WO claimed
US-20250085273-A1 NOVEL RAPID DRUG DISCOVERY FOR SEPSIS AND AGENTS FOR USE AS SEPSIS THERAPY THE GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF THE ARMY 2025-03-13 US claimed
US-20190046528-A1 METHOD OF PREVENTING HAIR LOSS OR PROMOTING HAIR GROWTH BY USING PHOSPHODIESTERASE 3 INHIBITOR SEOUL NATIONAL UNIVERSITY HOSPITAL (KR) 2019-02-14 US claimed
CN-102232088-A Anti-PCSK9 and methods for treating lipid and cholesterol disorders SCHERING CORP 2011-11-02 CN claimed
EP-1064935-B2 Solid delayed-release pharmaceutical compositions prepared by means of a thermoforming process SERVIER LAB (FR) 2011-06-08 EP claimed
US-20110020414-A1 MOISTURIZING RETINOL COMPOSITION THE BEAU SKIN LLC 2011-01-27 US claimed
US-20100221245-A1 TOPICAL SKIN CARE COMPOSITION DERMADOCTOR, LLC 2010-09-02 US claimed
EP-2205639-A2 ANTI-PCSK9 AND METHODS FOR TREATING LIPID AND CHOLESTEROL DISORDERS SCHERING CORPORATION (US) 2010-07-14 EP claimed
WO-2009055783-A2 ANTI-PCSK9 AND METHODS FOR TREATING LIPID AND CHOLESTEROL DISORDERS SCHERING CORPORATION (US) 2009-04-30 WO claimed
EP-1064935-B1 Solid controlled-release pharmaceutical compositions prepared by means of a thermoforming process SERVIER LAB (FR) 2008-05-14 EP claimed
EP-1785144-A2 Combinations of bile acids sequestrant(s) and sterol absorption inhibitor(s) and treatments for vascular indications Shering Corporation (US) 2007-05-16 EP claimed
EP-1541175-A2 Combinations of sterol absorption inhibitor(s) with cardiovascular agent(s) for the treatment of vascular conditions Schering Corporation (US) 2005-06-15 EP claimed
CN-1582168-A Combinations of sterol absorption inhibitor(s) with cardiovascular agent(s) for the treatment of vascular conditions SCHERING CORP (US) 2005-02-16 CN claimed
CN-1174744-C Solid thermoformable controlled release pharmaceutical composition ɪά��ʵ���� 2004-11-10 CN claimed
EP-1385548-A2 COMBINATIONS OF STEROL ABSORPTION INHIBITOR(S) WITH CARDIOVASCULAR AGENT(S) FOR THE TREATMENT OF VASCULAR CONDITIONS Schering Corporation (US) 2004-02-04 EP claimed
US-20030069221-A1 Combinations of sterol absorption inhibitor(s) with cardiovascular agent(s) for the treatment of vascular conditions SCHERING CORPORATION 2003-04-10 US claimed
WO-2002058731-A2 COMBINATIONS OF STEROL ABSORPTION INHIBITOR(S) WITH CARDIOVASCULAR AGENT(S) FOR THE TREATMENT OF VASCULAR CONDITIONS SCHERING CORPORATION (US) 2002-08-01 WO claimed
US-6319520-B1 COPOLYMERS OF AMMONIUM METHACRYLATE THAT CONSIST OF FULLY POLYMERIZED COPOLYMERS OF ACRYLIC ACID AND METHACRYLIC ACID ESTER HAVING QUATERNARY AMMONIUM GROUPS ADIR ET COMPAGNIE (FR) 2001-11-20 US claimed
CN-1285188-A Solid thermoformable controlled release pharmaceutical composition ADIR (FR) 2001-02-28 CN claimed
EP-1064935-A1 Solid thermoformable controlled-release pharmaceutical composition ADIR ET COMPAGNIE (FR) 2001-01-03 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030069221-A1 Combinations of sterol absorption inhibitor(s) with cardiovascular agent(s) for the treatment of vascular conditions CYP46A1, FABP2, SREBF1 CHRM2 4012/4885ADRA2A 815/4885DRD1 4539/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.