SCHEMBL1700678

SCHEMBL1700678

O=C(Nc1ccccc1)Nc1ccccc1Cl

nearest known ligand 0.87

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 9/20 0.87
▸ KMT2A Q03164 9/20 0.87
▸ RAB9A P51151 7/20 0.87
▸ MAPT P10636 6/20 0.87
▸ NPC1 O15118 6/20 0.87
▸ NPSR1 Q6W5P4 3/20 0.87
▸ POLB P06746 3/20 0.87
▸ KDM4E B2RXH2 3/20 0.87
▸ GAA P10253 1/20 0.87
▸ MAPK1 P28482 1/20 0.87
▸ TDP1 Q9NUW8 1/20 0.87
▸ LMNA P02545 5/20 0.77
▸ CASP3 P42574 2/20 0.75
▸ SENP7 Q9BQF6 2/20 0.75
▸ SENP8 Q96LD8 1/20 0.75
▸ SENP6 Q9GZR1 1/20 0.75
▸ SMN1; SMN2 Q16637 3/20 0.71
▸ HTT P42858 3/20 0.69
▸ TP53 P04637 1/20 0.65
▸ EPHX1 P07099 1/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23069069 0.93 MEN1 (0.76) MEN1KMT2ARAB9AMAPTNPC1
SCHEMBL10458447 0.90 KDM4E (0.72) MEN1KMT2ARAB9AMAPTNPC1
SCHEMBL10712301 0.89 MEN1 (0.76) MEN1KMT2ARAB9AMAPTNPC1
SCHEMBL10530781 0.87 MEN1 (1.00) MEN1KMT2ARAB9AMAPTNPC1
SCHEMBL24272326 0.87 MEN1 (0.73) MEN1KMT2ARAB9AMAPTNPC1
SCHEMBL4354878 0.86 MEN1 (0.73) MEN1KMT2ARAB9AMAPTNPC1
SCHEMBL5852172 0.86 RAB9A (0.71) MEN1KMT2ARAB9AMAPTNPC1
SCHEMBL11895913 0.86 MEN1 (0.71) MEN1KMT2ARAB9AMAPTNPC1
SCHEMBL31206308 0.86 RAB9A (0.71) MEN1KMT2ARAB9AMAPTNPC1
SCHEMBL21810514 0.86 SMN1; SMN2 (0.81) MEN1KMT2ARAB9AMAPTNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101325934-A Antimicrobial cellulosic sheet GEORGIA PACIFIC CONSUMER PROD (US) 2008-12-17 — — CN claimed
CN-101325949-A Lotion treated tissue and towel GEORGIA PACIFIC CONSUMER PROD (US) 2008-12-17 — — CN claimed
CN-1248285-A Toilet cleaning block RECKITT & COLMAN OF INDIA LTD (IN) 2000-03-22 — — CN claimed
WO-2024058975-A1 MODIFIED CHOLIC ACID CONJUGATES ULTRA, LLC (US) 2024-03-21 — — WO disclosed
US-20200383331-A1 COMPOSITIONS AND METHODS FOR LARGE-SCALE IN VITRO PLANT BIOCULTURE BOOSHOOT LLC (US) 2020-12-10 — — US disclosed
CN-110950802-A Synthesis process of intermediate of weight-reducing drug lorcaserin hydrochloride 江西博雅欣和制药有限公司 2020-04-03 — — CN disclosed
US-20190177308-A9 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 SENOMYX, INC. 2019-06-13 — — US disclosed
US-20180273517-A1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 SENOMYX INC (US) 2018-09-27 — — US disclosed
WO-2014191258-A2 ANTIMICROBIAL COMPOSITIONS COMPRISING GLYCERYL ETHERS SYMRISE AG (DE) 2014-12-04 — — WO disclosed
EP-2759199-A1 A method of providing antimicrobial action and a synergistic antimicrobial composition thereof Unilever N.V. (NL) 2014-07-30 — — EP disclosed
EP-2585571-A1 MACHINE DISHWASHING COMPOSITIONS AND METHODS Reckitt Benckiser N.V. (NL) 2013-05-01 — — EP disclosed
CN-1303261-A Hair conditioning composition comprising carboxylic acid/carboxylate copolymer and amphoteric conditioning agent PROCTER & GAMBLE (US) 2001-07-11 — — CN disclosed
CN-1303262-A Hair conditioning composition comprising carboxylic acid/carboxylate copolymer, silicone compound, and high melting point compound PROCTER & GAMBLE (US) 2001-07-11 — — CN disclosed
CN-1299270-A Antiperspirant compositions comprising 1, 2-hexanediol PROCTER & GAMBLE (US) 2001-06-13 — — CN disclosed
CN-1299271-A Deodorant composition comprising 1, 2-hexanediol PROCTER & GAMBLE (US) 2001-06-13 — — CN disclosed
CN-1248285-A Toilet cleaning block RECKITT & COLMAN OF INDIA LTD (IN) 2000-03-22 — — CN disclosed
US-5922660-A CLARITY; CONTAINING BACTERICIDE AND PYRROLIDINONE SOLUBILIZER COLGATE-PALMOLIVE CO. (US) 1999-07-13 — — US disclosed
CN-1159762-A Uncomplexed cyclodextrin solutions for odor control or inanimate surface PROCTER & GAMBLE (US) 1997-09-17 — — CN disclosed
US-5629276-A Composition of alkyl pyrrolidone for solubilizing antibacterials COLGATE-PALMOLIVE COMPANY (US) 1997-05-13 — — US disclosed
WO-1995030441-A1 COMPOSITION CONTAINING A SOLUBILIZED ANTIBACTERIAL AGENT COLGATE-PALMOLIVE COMPANY (US) 1995-11-16 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200383331-A1 COMPOSITIONS AND METHODS FOR LARGE-SCALE IN VITRO PLANT BIOCULTURE MYB, MYCBP, PIM1 MEN1 3748/4885KMT2A 2151/4885RAB9A 4167/4885
US-20190177308-A9 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 TRPM8, TRPM6, TRPM4 MEN1 1247/4885KMT2A 4178/4885RAB9A 1959/4885
US-20180273517-A1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 TRPM8, TRPM6, TRPM4 MEN1 1247/4885KMT2A 4178/4885RAB9A 1959/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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