SCHEMBL1700833

SCHEMBL1700833

CC(=O)Oc1cccc(F)c1F

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 1/20 0.49
KDM4E B2RXH2 3/20 0.48
PTGS2 P35354 3/20 0.48
HSD17B10 Q99714 2/20 0.48
ALDH1A1 P00352 2/20 0.48
BLM P54132 2/20 0.48
TDP1 Q9NUW8 2/20 0.48
ESR1 P03372 1/20 0.48
ITGB3 P05106 1/20 0.48
ITGA2B P08514 1/20 0.48
HMGB1 P09429 1/20 0.48
HPGD P15428 1/20 0.48
TSHR P16473 1/20 0.48
GGT1 P19440 1/20 0.48
PTGS1 P23219 1/20 0.48
NAPRT Q6XQN6 1/20 0.48
KMT2A Q03164 3/20 0.47
ACHE P22303 1/20 0.47
CYP4F2 P78329 1/20 0.46
CYP4A11 Q02928 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31200468 1.00 MAPK1 (0.49) MAPK1KDM4EPTGS2HSD17B10ALDH1A1
SCHEMBL25329639 0.98 MAPK1 (0.47) MAPK1KDM4EPTGS2HSD17B10ALDH1A1
SCHEMBL247351 0.83 PTGS2 (0.57) MAPK1KDM4EPTGS2HSD17B10ALDH1A1
SCHEMBL15836535 0.83 KMT2A (0.44) MAPK1ALDH1A1TDP1KMT2ACES2
SCHEMBL17355729 0.82 PTPN1 (0.53) MAPK1KDM4EPTGS2HSD17B10ALDH1A1
SCHEMBL6200625 0.82 MAPK1 (0.47) MAPK1KDM4EPTGS2HSD17B10ALDH1A1
SCHEMBL28691323 0.82 MAPK1 (0.47) MAPK1KDM4EPTGS2HSD17B10ALDH1A1
SCHEMBL6194083 0.82 MAPK1 (0.47) MAPK1KDM4EPTGS2HSD17B10ALDH1A1
SCHEMBL868843 0.82 ACHE (0.59) MAPK1KDM4EPTGS2HSD17B10ALDH1A1
SCHEMBL156400 0.82 CYP4F2 (0.51) MAPK1KDM4EPTGS2HSD17B10ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 119 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10483466-B2 P-doping cross-linking of organic hole transporters SIEMENS AKTIENGESELLSCHAFT (DE) 2019-11-19 US claimed
EP-3114715-B1 P-DOPING CROSS-LINKING OF ORGANIC HOLE TRANSPORTERS SIEMENS AG (DE) 2019-10-30 EP claimed
US-20180198069-A1 P-Doping Cross-Linking Of Organic Hole Transporters SIEMENS AKTIENGESELLSCHAFT (DE) 2018-07-12 US claimed
US-8952083-B2 Fluorocopolymer composition and its production process ASAHI GLASS COMPANY, LIMITED (JP) 2015-02-10 US claimed
CN-101486638-B Preparation of 2,3-difluorophenylacetic acid ZHEJIANG YONGTAI TECHNOLOGY CO LTD 2013-02-20 CN claimed
CN-101837303-A Novel nickel catalyst and preparation method and application thereof SHANGHAI WANSHUO CHEMICAL CO LTD 2010-09-22 CN claimed
EP-4531919-A1 METHOD OF TREATING VITILIGO WITH INTERFERON-GAMMA ANTIBODY Elixiron Immunotherapeutics (Hong Kong) Limited (HK) 2025-04-09 EP disclosed
WO-2024259241-A1 5-HT2A RECEPTOR MODULATORS AND METHODS OF USE THEREOF Transneural Therapeutics, Inc. (US) 2024-12-19 WO disclosed
US-20240408106-A1 BI-FUNCTIONAL COMPOUNDS AND METHODS FOR TARGETED UBIQUITINATION OF ANDROGEN RECEPTOR DBD THERAPEUTICS, LLC 2024-12-12 US disclosed
US-20240376118-A1 BI-FUNCTIONAL COMPOUNDS AND METHODS FOR TARGETED UBIQUITINATION OF ANDROGEN RECEPTOR DBD THERAPEUTICS, LLC 2024-11-14 US disclosed
US-20240317734-A1 BI-FUNCTIONAL COMPOUNDS AND METHODS FOR TARGETED UBIQUITINATION OF ANDROGEN RECEPTOR DBD THERAPEUTICS, LLC 2024-09-26 US disclosed
US-20240207415-A1 BI-FUNCTIONAL COMPOUNDS AND METHODS FOR TARGETED UBIQUITINATION OF ANDROGEN RECEPTOR DBD THERAPEUTICS, LLC 2024-06-27 US disclosed
US-20240207415-A1 BI-FUNCTIONAL COMPOUNDS AND METHODS FOR TARGETED UBIQUITINATION OF ANDROGEN RECEPTOR DBD THERAPEUTICS, LLC 2024-06-27 US disclosed
WO-2005056530-A1 BENZOYL AMINO PYRIDYL CARBOXYLIC ACID DERIVATIVES USEFUL AS GLUCOKINASE (GLK) ACTIVATORS ASTRAZENECA AB (SE) 2005-06-23 WO disclosed
EP-0950669-B1 Method of catalytic crosslinking of polymers and two-pack composition used therein ROHM & HAAS (US) 2004-09-08 EP disclosed
EP-1150962-A1 PROCESS FOR THE PREPARATION OF 6-(PERFLUOROALKYL)URACIL COMPOUNDS FROM CARBAMATE COMPOUNDS AMERICAN CYANAMID COMPANY (US) 2001-11-07 EP disclosed
US-6306991-B1 TWO PART COATING COMPOSITION WITH TWO CONTAINERS, OXIDATIVE POLYMERS WITH CROSSLINKABLE FUNCTIONAL GROUPS ROHM AND HAAS COMPANY 2001-10-23 US disclosed
US-6149977-A CONTACTING THE OXIDATIVE POLYMER WITH A CATALYTIC AMOUNT OF AN OXIDIZING ENZYME, SUCH AS HORSERADISH PEROXIDASE. ROHM AND HAAS COMPANY (US) 2000-11-21 US disclosed
WO-2000049003-A1 PROCESS FOR THE PREPARATION OF 6-(PERFLUOROALKYL)URACIL COMPOUNDS FROM CARBAMATE COMPOUNDS AMERICAN CYANAMID COMPANY (US) 2000-08-24 WO disclosed
EP-0950669-A2 Method of catalytic crosslinking of polymers and two-pack composition used therein ROHM AND HAAS COMPANY (US) 1999-10-20 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240376118-A1 BI-FUNCTIONAL COMPOUNDS AND METHODS FOR TARGETED UBIQUITINATION OF ANDROGEN RECEPTOR AR, ADRM1, PSMA3 MAPK1 4357/4885KDM4E 669/4885PTGS2 4413/4885
US-20240207415-A1 BI-FUNCTIONAL COMPOUNDS AND METHODS FOR TARGETED UBIQUITINATION OF ANDROGEN RECEPTOR AR, ADRM1, PSMA3 MAPK1 4357/4885KDM4E 669/4885PTGS2 4413/4885
US-20240408106-A1 BI-FUNCTIONAL COMPOUNDS AND METHODS FOR TARGETED UBIQUITINATION OF ANDROGEN RECEPTOR AR, ADRM1, PSMA3 MAPK1 4357/4885KDM4E 669/4885PTGS2 4413/4885
US-20240317734-A1 BI-FUNCTIONAL COMPOUNDS AND METHODS FOR TARGETED UBIQUITINATION OF ANDROGEN RECEPTOR AR, ADRM1, PSMA3 MAPK1 4357/4885KDM4E 669/4885PTGS2 4413/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.