Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.79 |
| ▸ | MAPT | P10636 | 3/20 | 0.79 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.79 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.79 |
| ▸ | USP2 | O75604 | 1/20 | 0.79 |
| ▸ | LMNA | P02545 | 1/20 | 0.79 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.79 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.79 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.79 |
| ▸ | HTT | P42858 | 1/20 | 0.79 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.79 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.79 |
| ▸ | RELA | Q04206 | 1/20 | 0.79 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.79 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.79 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.79 |
| ▸ | GRK6 | P43250 | 2/20 | 0.70 |
| ▸ | MDM2 | Q00987 | 6/20 | 0.69 |
| ▸ | P4HB | P07237 | 1/20 | 0.63 |
| ▸ | CD74 | P04233 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15783167 | 0.92 | MAPT (0.70) | TP53MAPTSMN1; SMN2KDM4EUSP2 | |
| SCHEMBL16810181 | 0.88 | TP53 (1.00) | TP53MAPTSMN1; SMN2KDM4EUSP2 | |
| SCHEMBL18197735 | 0.88 | TP53 (0.79) | TP53MAPTSMN1; SMN2KDM4ELMNA | |
| SCHEMBL18131609 | 0.87 | MDM2 (0.76) | TP53MAPTSMN1; SMN2KDM4EUSP2 | |
| SCHEMBL1700871 | 0.87 | MDM2 (0.76) | TP53MAPTSMN1; SMN2KDM4EUSP2 | |
| SCHEMBL18131661 | 0.87 | MDM2 (0.76) | TP53MAPTSMN1; SMN2KDM4EUSP2 | |
| SCHEMBL18131660 | 0.86 | MDM2 (0.63) | TP53MAPTSMN1; SMN2KDM4EUSP2 | |
| SCHEMBL19092983 | 0.86 | MDM2 (0.63) | TP53MAPTSMN1; SMN2KDM4EUSP2 | |
| SCHEMBL21519373 | 0.86 | MDM2 (0.63) | TP53MAPTSMN1; SMN2KDM4EUSP2 | |
| SCHEMBL16810106 | 0.85 | MAPT (0.79) | TP53MAPTSMN1; SMN2KDM4EUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566849-A1 | 8-HYDROXY-QUINOLINE DERIVATIVES | "Avidin" Kutató, Fejleszt És Kereskedelmi Korlatolt Felelossegu Tarsasag (HU) | 2013-03-13 | — | — | EP | claimed |
| WO-2011148208-A1 | 8-HYDROXY-QUINOLINE DERIVATIVES | "AVIDIN" KUTATÓ, FEJLESZTŐ ÉS KERESKEDELMI KORLÁTOLT FELELŐSSÉGŰ TÁRSASÁG (HU) | 2011-12-01 | — | — | WO | claimed |
| EP-3079697-B1 | PROLYLHYDROXYLASE/ATF4 INHIBITORS FOR TREATING NEURAL CELL INJURY | UNIV CORNELL (US) | 2021-02-03 | — | — | EP | disclosed |
| US-20200360366-A1 | PROLYLHYDROXYLASE/ATF4 INHIBITORS AND METHODS OF USE FOR TREATING NEURAL CELL INJURY OR DEATH AND CONDITIONS RESULTING THEREFROM | CORNELL UNIVERSITY (US) | 2020-11-19 | — | — | US | disclosed |
| EP-2566849-B1 | 8-HYDROXY-QUINOLINE DERIVATIVES | AVIDIN KUTATO FEJLESZTOE ES KERESKEDELMI KORLATOLT FELELOESSEGUE TARSASAG (HU) | 2019-09-18 | — | — | EP | disclosed |
| EP-2566849-B1 | 8-HYDROXY-QUINOLINE DERIVATIVES | AVIDIN KUTATO FEJLESZTOE ES KERESKEDELMI KORLATOLT FELELOESSEGUE TARSASAG (HU) | 2019-09-18 | — | — | EP | disclosed |
| US-20150272939-A1 | Identification of Small Molecule Inhibitors of Jumonji AT-Rich Interactive Domain 1A (JARID1A) and 1B (JARID1B) Histone Demethylase | YALE UNIVERSITY (US) | 2015-10-01 | — | — | US | disclosed |
| US-20150272939-A1 | Identification of Small Molecule Inhibitors of Jumonji AT-Rich Interactive Domain 1A (JARID1A) and 1B (JARID1B) Histone Demethylase | YALE UNIVERSITY (US) | 2015-10-01 | — | — | US | disclosed |
| WO-2015089416-A1 | PROLYLHYDROXYLASE/ATF4 INHIBITORS FOR TREATING NEURAL CELL INJURY | CORNELL UNIVERSITY (US) | 2015-06-18 | — | — | WO | disclosed |
| US-8871937-B2 | 8-hydroxy-quinoline derivatives | “AVIDIN” Kutato, Fejleszto es Kereskedelmi Korlatolt Felelossegu Tarsasag (HU) | 2014-10-28 | — | — | US | disclosed |
| US-8871937-B2 | 8-hydroxy-quinoline derivatives | “AVIDIN” Kutato, Fejleszto es Kereskedelmi Korlatolt Felelossegu Tarsasag (HU) | 2014-10-28 | — | — | US | disclosed |
| US-20130131096-A1 | 8-HYDROXY-QUINOLINE DERIVATIVES | UBICHEM KUTATO KORLATOLT FELELOSSEGU TARSASAG (HU) | 2013-05-23 | — | — | US | disclosed |
| US-20130131096-A1 | 8-HYDROXY-QUINOLINE DERIVATIVES | UBICHEM KUTATO KORLATOLT FELELOSSEGU TARSASAG (HU) | 2013-05-23 | — | — | US | disclosed |
| WO-2011148208-A1 | 8-HYDROXY-QUINOLINE DERIVATIVES | "AVIDIN" KUTATÓ, FEJLESZTŐ ÉS KERESKEDELMI KORLÁTOLT FELELŐSSÉGŰ TÁRSASÁG (HU) | 2011-12-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200360366-A1 | PROLYLHYDROXYLASE/ATF4 INHIBITORS AND METHODS OF USE FOR TREATING NEURAL CELL INJURY OR DEATH AND CONDITIONS RESULTING THEREFROM | ATF4, P4HTM, P4HA1 | TP53 2913/4885MAPT 1958/4885SMN1; SMN2 130/4885 |
| US-20130131096-A1 | 8-HYDROXY-QUINOLINE DERIVATIVES | CYP2C8, NQO1, KEAP1 | TP53 4173/4885MAPT 2319/4885SMN1; SMN2 1845/4885 |
| US-20150272939-A1 | Identification of Small Molecule Inhibitors of Jumonji AT-Rich Interactive Domain 1A (JARID1A) and 1B (JARID1B) Histone Demethylase | KDM1B, KDM1A, JMJD1C | TP53 3089/4885MAPT 4286/4885SMN1; SMN2 3955/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.