Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 7/20 | 0.76 |
| ▸ | MAPT | P10636 | 8/20 | 0.68 |
| ▸ | TP53 | P04637 | 7/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.68 |
| ▸ | P4HB | P07237 | 5/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
| ▸ | THRB | P10828 | 1/20 | 0.61 |
| ▸ | JMJD7 | P0C870 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18131609 | 1.00 | MDM2 (0.76) | MDM2MAPTTP53SMN1; SMN2P4HB | |
| SCHEMBL18131661 | 1.00 | MDM2 (0.76) | MDM2MAPTTP53SMN1; SMN2P4HB | |
| SCHEMBL15783093 | 0.89 | MAPT (0.80) | MDM2MAPTTP53SMN1; SMN2P4HB | |
| SCHEMBL9965620 | 0.89 | MDM2 (0.86) | MDM2MAPTTP53SMN1; SMN2P4HB | |
| SCHEMBL9965628 | 0.88 | TP53 (0.77) | MDM2MAPTTP53SMN1; SMN2P4HB | |
| SCHEMBL18197735 | 0.88 | TP53 (0.79) | MDM2MAPTTP53SMN1; SMN2P4HB | |
| SCHEMBL15783201 | 0.87 | P4HB (0.81) | MDM2MAPTTP53SMN1; SMN2P4HB | |
| SCHEMBL1700855 | 0.87 | TP53 (0.79) | MDM2MAPTTP53SMN1; SMN2P4HB | |
| SCHEMBL9965573 | 0.86 | MDM2 (1.00) | MDM2MAPTTP53SMN1; SMN2P4HB | |
| SCHEMBL18131665 | 0.86 | MDM2 (0.74) | MDM2MAPTTP53SMN1; SMN2P4HB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130131096-A1 | 8-HYDROXY-QUINOLINE DERIVATIVES | UBICHEM KUTATO KORLATOLT FELELOSSEGU TARSASAG (HU) | 2013-05-23 | — | — | US | claimed |
| EP-2566849-A1 | 8-HYDROXY-QUINOLINE DERIVATIVES | "Avidin" Kutató, Fejleszt És Kereskedelmi Korlatolt Felelossegu Tarsasag (HU) | 2013-03-13 | — | — | EP | claimed |
| WO-2011148208-A1 | 8-HYDROXY-QUINOLINE DERIVATIVES | "AVIDIN" KUTATÓ, FEJLESZTŐ ÉS KERESKEDELMI KORLÁTOLT FELELŐSSÉGŰ TÁRSASÁG (HU) | 2011-12-01 | — | — | WO | claimed |
| US-20190330188-A1 | ENANTIOMERS OF 8-HYDROXYQUINOLINE DERIVATIVES AND THE SYNTHESIS THEREOF | AVIDIN CO. LTD (HU) | 2019-10-31 | — | — | US | disclosed |
| EP-2566849-B1 | 8-HYDROXY-QUINOLINE DERIVATIVES | AVIDIN KUTATO FEJLESZTOE ES KERESKEDELMI KORLATOLT FELELOESSEGUE TARSASAG (HU) | 2019-09-18 | — | — | EP | disclosed |
| EP-2566849-B1 | 8-HYDROXY-QUINOLINE DERIVATIVES | AVIDIN KUTATO FEJLESZTOE ES KERESKEDELMI KORLATOLT FELELOESSEGUE TARSASAG (HU) | 2019-09-18 | — | — | EP | disclosed |
| US-10287265-B2 | Enantiomers of 8-hydroxyquinoline derivatives and the synthesis thereof | AVIDIN CO. LTD. (HU) | 2019-05-14 | — | — | US | disclosed |
| US-8871937-B2 | 8-hydroxy-quinoline derivatives | “AVIDIN” Kutato, Fejleszto es Kereskedelmi Korlatolt Felelossegu Tarsasag (HU) | 2014-10-28 | — | — | US | disclosed |
| US-8871937-B2 | 8-hydroxy-quinoline derivatives | “AVIDIN” Kutato, Fejleszto es Kereskedelmi Korlatolt Felelossegu Tarsasag (HU) | 2014-10-28 | — | — | US | disclosed |
| US-8871937-B2 | 8-hydroxy-quinoline derivatives | “AVIDIN” Kutato, Fejleszto es Kereskedelmi Korlatolt Felelossegu Tarsasag (HU) | 2014-10-28 | — | — | US | disclosed |
| US-20130131096-A1 | 8-HYDROXY-QUINOLINE DERIVATIVES | UBICHEM KUTATO KORLATOLT FELELOSSEGU TARSASAG (HU) | 2013-05-23 | — | — | US | disclosed |
| US-20130131096-A1 | 8-HYDROXY-QUINOLINE DERIVATIVES | UBICHEM KUTATO KORLATOLT FELELOSSEGU TARSASAG (HU) | 2013-05-23 | — | — | US | disclosed |
| US-20130131096-A1 | 8-HYDROXY-QUINOLINE DERIVATIVES | UBICHEM KUTATO KORLATOLT FELELOSSEGU TARSASAG (HU) | 2013-05-23 | — | — | US | disclosed |
| WO-2011148208-A1 | 8-HYDROXY-QUINOLINE DERIVATIVES | "AVIDIN" KUTATÓ, FEJLESZTŐ ÉS KERESKEDELMI KORLÁTOLT FELELŐSSÉGŰ TÁRSASÁG (HU) | 2011-12-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10287265-B2 | Enantiomers of 8-hydroxyquinoline derivatives and the synthesis thereof | TPH1, HTR5A, TPH2 | MDM2 3814/4885MAPT 3429/4885TP53 4452/4885 |
| US-20190330188-A1 | ENANTIOMERS OF 8-HYDROXYQUINOLINE DERIVATIVES AND THE SYNTHESIS THEREOF | TPH1, TPH2, HTR5A | MDM2 2226/4885MAPT 2690/4885TP53 3980/4885 |
| US-20130131096-A1 | 8-HYDROXY-QUINOLINE DERIVATIVES | CYP2C8, NQO1, KEAP1 | MDM2 2015/4885MAPT 2319/4885TP53 4173/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.