Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL227505 | 0.85 | HRH3 (0.61) | GPR6HRH3 | |
| SCHEMBL1560104 | 0.85 | PDE4B (0.45) | GPR6HRH3 | |
| SCHEMBL28291788 | 0.83 | GPR6 (0.51) | GPR6 | |
| SCHEMBL23686797 | 0.81 | SLC6A9 (0.47) | GPR6 | |
| SCHEMBL18855637 | 0.81 | SLC6A9 (0.47) | GPR6HRH3 | |
| SCHEMBL223791 | 0.80 | GPR119 (0.64) | GPR6 | |
| SCHEMBL13726479 | 0.80 | FPR2 (0.51) | GPR6 | |
| SCHEMBL17009599 | 0.80 | GPR119 (0.43) | GPR6HRH3 | |
| SCHEMBL227139 | 0.80 | GPR6 (0.58) | GPR6 | |
| SCHEMBL29826343 | 0.80 | GPR6 (0.41) | GPR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3105216-A1 | PYRAZINES MODULATORS OF GPR6 | Takeda Pharmaceutical Company Limited (JP) | 2016-12-21 | — | — | EP | disclosed |
| EP-3105230-A1 | PYRIDOPYRAZINES MODULATORS OF GPR6 | Takeda Pharmaceutical Company Limited (JP) | 2016-12-21 | — | — | EP | disclosed |
| WO-2015123533-A1 | PYRAZINES MODULATORS OF GPR6 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-08-20 | — | — | WO | disclosed |
| WO-2015123505-A1 | PYRIDOPYRAZINES MODULATORS OF GPR6 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-08-20 | — | — | WO | disclosed |