Sugi Predict

Sugi Predict / Compounds / SCHEMBL17009677

SCHEMBL17009677

SCHEMBL17009677

Cn1c(C(=O)OC(C)(C)C)cc2cc(N)ccc21

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ L3MBTL1 Q9Y468 1/20 0.50
▸ BRPF1 P55201 2/20 0.47
▸ KDM4E B2RXH2 2/20 0.43
▸ ALDH1A1 P00352 2/20 0.43
▸ HPGD P15428 2/20 0.43
▸ HSD17B10 Q99714 2/20 0.43
▸ SMN1; SMN2 Q16637 1/20 0.43
▸ MCL1 Q07820 2/20 0.42
▸ GALR3 O60755 1/20 0.40
▸ GAA P10253 1/20 0.40
▸ NR1H2 P55055 1/20 0.39
▸ DYRK1B Q9Y463 2/20 0.38
▸ CHEK1 O14757 1/20 0.38
▸ AURKA O14965 1/20 0.38
▸ DAPK3 O43293 1/20 0.38
▸ CSNK1A1 P48729 1/20 0.38
▸ GSK3A P49840 1/20 0.38
▸ LIMK1 P53667 1/20 0.38
▸ IKBKE Q14164 1/20 0.38
▸ MAPK14 Q16539 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3061254 0.84 L3MBTL1 (0.70) L3MBTL1BRPF1KDM4EALDH1A1HPGD
SCHEMBL23176776 0.83 NR1H2 (0.42) BRPF1NR1H2DYRK1BCHEK1AURKA
SCHEMBL29524657 0.83 NR1H2 (0.42) BRPF1NR1H2DYRK1BCHEK1AURKA
SCHEMBL17995256 0.81 MCL1 (0.61) L3MBTL1MCL1MAPTSLC9A1
SCHEMBL1173839 0.80 MAPT (0.52) L3MBTL1BRPF1KDM4EALDH1A1HPGD
SCHEMBL15712283 0.79 CCR2 (0.40) KDM4EALDH1A1HPGDGAANR1H2
SCHEMBL17009986 0.79 CYP19A1 (0.49) L3MBTL1KDM4EALDH1A1HPGDHSD17B10
SCHEMBL6969376 0.79 HSD17B10 (0.66) L3MBTL1BRPF1KDM4EALDH1A1HPGD
SCHEMBL17060360 0.77 CCR2 (0.54) MAPTTHRBCCR2
SCHEMBL6617414 0.76 L3MBTL1 (0.43) L3MBTL1GAANR1H2AURKA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116283750-B Heterocyclic amide derivative and preparation method and application thereof 成都泰和伟业生物科技有限公司 2025-02-07 — — CN disclosed
CN-116283750-A Heterocyclic amide derivative and preparation method and application thereof 成都泰和伟业生物科技有限公司 2023-06-23 — — CN disclosed
CN-116199672-A Pyrimidine amide derivative and preparation method and application thereof 成都泰和伟业生物科技有限公司 2023-06-02 — — CN disclosed
CN-114728914-B Dioxopiperazine derivative, preparation method thereof and application thereof in medicines 深圳信立泰药业股份有限公司 2023-05-12 — — CN disclosed
CN-114728914-A Dioxopiperazine derivative, preparation method and medical application thereof 深圳信立泰药业股份有限公司 2022-07-08 — — CN disclosed
EP-3138839-B1 PYRIDONE OR PYRIMIDONE DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF SICHUAN HAISCO PHARMACEUTICAL CO LTD (CN) 2020-10-28 — — EP disclosed
CN-105829298-B A kind of pyridone or pyrimidone derivatives, and its preparation method and application 四川海思科制药有限公司 2019-02-01 — — CN disclosed
US-10174020-B2 Pyridone or pyrimidone derivative, preparation method therefor and application thereof SICHUAN HAISCO PHARMACEUTICAL CO., LTD. (CN) 2019-01-08 — — US disclosed
US-10174020-B2 Pyridone or pyrimidone derivative, preparation method therefor and application thereof SICHUAN HAISCO PHARMACEUTICAL CO., LTD. (CN) 2019-01-08 — — US disclosed
EP-3138839-A1 PYRIDONE OR PYRIMIDONE DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF Sichuan Haisco Pharmaceutical Co., Ltd. (CN) 2017-03-08 — — EP disclosed
EP-3138839-A1 PYRIDONE OR PYRIMIDONE DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF Sichuan Haisco Pharmaceutical Co., Ltd. (CN) 2017-03-08 — — EP disclosed
US-20170029423-A1 PYRIDONE OR PYRIMIDONE DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF SICHUAN HAISCO PHARMACEUTICAL CO., LTD. (CN) 2017-02-02 — — US disclosed
US-20170029423-A1 PYRIDONE OR PYRIMIDONE DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF SICHUAN HAISCO PHARMACEUTICAL CO., LTD. (CN) 2017-02-02 — — US disclosed
US-20170029423-A1 PYRIDONE OR PYRIMIDONE DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF SICHUAN HAISCO PHARMACEUTICAL CO., LTD. (CN) 2017-02-02 — — US disclosed
CN-105829298-A Pyridone or pyrimidone derivative, preparation method therefor and application thereof 四川海思科制药有限公司 2016-08-03 — — CN disclosed
WO-2015120777-A1 PYRIDONE OR PYRIMIDONE DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF 四川海思科制药有限公司 2015-08-20 — — WO disclosed
WO-2015120777-A1 PYRIDONE OR PYRIMIDONE DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF 四川海思科制药有限公司 2015-08-20 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10174020-B2 Pyridone or pyrimidone derivative, preparation method therefor and application thereof TYMP, DHFR, TYMS L3MBTL1 4397/4885BRPF1 328/4885KDM4E 3256/4885
US-20170029423-A1 PYRIDONE OR PYRIMIDONE DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF TYMP, DHFR, TYMS L3MBTL1 4397/4885BRPF1 328/4885KDM4E 3256/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.