Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1701353 | 0.72 | CHRNB2 (0.33) | LMNA | |
| Hydrochloric Acid SCHEMBL1701151 | 0.71 | CHRNB2 (0.32) | LMNA | |
| SCHEMBL26934727 | 0.64 | CHRNB2 (0.32) | LMNA | |
| SCHEMBL26934713 | 0.64 | CHRNB2 (0.32) | LMNA | |
| SCHEMBL6290928 | 0.63 | — | — | |
| SCHEMBL14721460 | 0.62 | CHRNB2 (0.31) | LMNA | |
| SCHEMBL11808388 | 0.59 | TRPA1 (0.32) | — | |
| SCHEMBL4612940 | 0.55 | — | — | |
| SCHEMBL10358961 | 0.55 | ALDH1A1 (0.33) | ALDH1A1 | |
| SCHEMBL11318339 | 0.55 | ALDH1A1 (0.33) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10716770-B2 | Nicotinic receptor non-competitive antagonists | CATALYST BIOSCIENCES, INC. (US) | 2020-07-21 | — | — | US | disclosed |
| US-20190254991-A1 | Nicotinic Receptor Non-Competitive Antagonists | CATALYST BIOSCIENCES INC (US) | 2019-08-22 | — | — | US | disclosed |
| US-10258582-B2 | Nicotinic receptor non-competitive antagonists | CATALYST BIOSCIENCES, INC. (US) | 2019-04-16 | — | — | US | disclosed |
| US-20180271806-A1 | NICOTINIC RECEPTOR NON-COMPETITIVE ANTAGONISTS | CATALYST BIOSCIENCES, INC. | 2018-09-27 | — | — | US | disclosed |
| US-20170071878-A1 | NICOTINIC RECEPTOR NON-COMPETITIVE ANTAGONISTS | CATALYST BIOSCIENCES INC (US) | 2017-03-16 | — | — | US | disclosed |
| EP-2576496-B1 | NICOTINIC RECEPTOR NON-COMPETITIVE ANTAGONISTS | CATALYST BIOSCIENCES INC (US) | 2017-03-08 | — | — | EP | disclosed |
| US-9532974-B2 | Nicotinic receptor non-competitive antagonists | TARGACEPT, INC. (US) | 2017-01-03 | — | — | US | disclosed |
| US-20160008323-A1 | NICOTINIC RECEPTOR NON-COMPETITIVE ANTAGONISTS | TARGACEPT INC (US) | 2016-01-14 | — | — | US | disclosed |
| US-20140315877-A1 | NICOTINIC RECEPTOR NON-COMPETITIVE ANTAGONISTS | TARGACEPT INC (US) | 2014-10-23 | — | — | US | disclosed |
| US-8809397-B2 | Nicotinic receptor non-competitive antagonists | TARGACEPT, INC. (US) | 2014-08-19 | — | — | US | disclosed |
| US-20130203860-A1 | NICOTINIC RECEPTOR NON-COMPETITIVE ANTAGONISTS | TARGACEPT, INC. | 2013-08-08 | — | — | US | disclosed |
| EP-2576496-A1 | NICOTINIC RECEPTOR NON-COMPETITIVE ANTAGONISTS | Targacept, Inc. (US) | 2013-04-10 | — | — | EP | disclosed |
| WO-2011149859-A1 | NICOTINIC RECEPTOR NON-COMPETITIVE ANTAGONISTS | TARGACEPT, INC. (US) | 2011-12-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10258582-B2 | Nicotinic receptor non-competitive antagonists | CHRNA5, CHRNA2, CHRNG | ALDH1A1 2280/4885LMNA 4132/4885THRB 359/4885 |
| US-20160008323-A1 | NICOTINIC RECEPTOR NON-COMPETITIVE ANTAGONISTS | CHRNA5, CHRNA2, CHRNG | ALDH1A1 2280/4885LMNA 4132/4885THRB 359/4885 |
| US-20180271806-A1 | NICOTINIC RECEPTOR NON-COMPETITIVE ANTAGONISTS | CHRNA5, CHRNA2, CHRNG | ALDH1A1 2280/4885LMNA 4132/4885THRB 359/4885 |
| US-20130203860-A1 | NICOTINIC RECEPTOR NON-COMPETITIVE ANTAGONISTS | CHRNA5, CHRNA2, CHRNG | ALDH1A1 2280/4885LMNA 4132/4885THRB 359/4885 |
| US-20170071878-A1 | NICOTINIC RECEPTOR NON-COMPETITIVE ANTAGONISTS | CHRNA5, CHRNA2, CHRNG | ALDH1A1 2280/4885LMNA 4132/4885THRB 359/4885 |
| US-10716770-B2 | Nicotinic receptor non-competitive antagonists | CHRNA5, CHRNA2, CHRNG | ALDH1A1 2063/4885LMNA 4210/4885THRB 361/4885 |
| US-20190254991-A1 | Nicotinic Receptor Non-Competitive Antagonists | CHRNA5, CHRNA2, CHRNG | ALDH1A1 2063/4885LMNA 4210/4885THRB 361/4885 |
| US-20140315877-A1 | NICOTINIC RECEPTOR NON-COMPETITIVE ANTAGONISTS | CHRNA5, CHRNA2, CHRNG | ALDH1A1 2280/4885LMNA 4132/4885THRB 359/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.