SCHEMBL17012357

SCHEMBL17012357

c1ccc(-c2c3c(c(-c4ccccc4)c4ccccc24)-c2ccc(N(c4ccncc4)c4cccc5ccccc45)c4cccc-3c24)cc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TNF P01375 1/20 0.39
▸ MAPT P10636 6/20 0.35
▸ KDM4E B2RXH2 6/20 0.35
▸ ALDH1A1 P00352 5/20 0.35
▸ HPGD P15428 4/20 0.35
▸ LMNA P02545 3/20 0.34
▸ MAPK1 P28482 3/20 0.34
▸ SMN1; SMN2 Q16637 3/20 0.34
▸ HSD17B10 Q99714 2/20 0.34
▸ RAB9A P51151 2/20 0.34
▸ NPC1 O15118 1/20 0.34
▸ MAPK11 Q15759 2/20 0.33
▸ MAPK14 Q16539 2/20 0.33
▸ TDP1 Q9NUW8 2/20 0.33
▸ SIGMAR1 Q99720 1/20 0.33
▸ ENPP1 P22413 1/20 0.32
▸ TP53 P04637 1/20 0.32
▸ TSHR P16473 1/20 0.32
▸ NFKB1 P19838 1/20 0.32
▸ NFKB2 Q00653 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17012353 0.91 MEN1 (0.34) TNFMAPTKDM4EALDH1A1HPGD
SCHEMBL16484333 0.90 MEN1 (0.33) TNFMAPTKDM4EALDH1A1HPGD
SCHEMBL16485319 0.90 TNF (0.42) TNFMAPTKDM4EALDH1A1HPGD
SCHEMBL16484470 0.90 TNF (0.39) TNFMAPTKDM4EALDH1A1HPGD
SCHEMBL16484425 0.90 TNF (0.48) TNFMAPTKDM4EALDH1A1HPGD
SCHEMBL17012383 0.89 CYP11B1 (0.35) TNFMAPTKDM4EALDH1A1HPGD
SCHEMBL16483994 0.88 TNF (0.38) TNFMAPTKDM4EALDH1A1HPGD
SCHEMBL17132490 0.87 TNF (0.39) TNFMAPTKDM4EALDH1A1HPGD
SCHEMBL17012368 0.86 MAPT (0.35) TNFMAPTKDM4EALDH1A1HPGD
SCHEMBL17132460 0.86 ALDH1A1 (0.39) TNFMAPTKDM4EALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2907803-B1 FLUORANTHENE DERIVATIVE, LUMINESCENT ELEMENT MATERIAL CONTAINING SAME, AND LUMINESCENT ELEMENT TORAY INDUSTRIES (JP) 2021-08-18 — — EP disclosed
US-9935273-B2 Fluoranthene derivative, light-emitting device material containing same, and light-emitting device TORAY INDUSTRIES, INC. (JP) 2018-04-03 — — US disclosed
US-20150280139-A1 FLUORANTHENE DERIVATIVE, LIGHT-EMITTING DEVICE MATERIAL CONTAINING SAME, AND LIGHT-EMITTING DEVICE TORAY INDUSTRIES, INC. (JP) 2015-10-01 — — US disclosed
US-20150280139-A1 FLUORANTHENE DERIVATIVE, LIGHT-EMITTING DEVICE MATERIAL CONTAINING SAME, AND LIGHT-EMITTING DEVICE TORAY INDUSTRIES, INC. (JP) 2015-10-01 — — US disclosed
EP-2907803-A1 FLUORANTHENE DERIVATIVE, LUMINESCENT ELEMENT MATERIAL CONTAINING SAME, AND LUMINESCENT ELEMENT Toray Industries, Inc. (JP) 2015-08-19 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150280139-A1 FLUORANTHENE DERIVATIVE, LIGHT-EMITTING DEVICE MATERIAL CONTAINING SAME, AND LIGHT-EMITTING DEVICE FMNL1, AFF2, LEF1 TNF 3654/4885MAPT 937/4885KDM4E 502/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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