Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | THPO | P40225 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | STAT6 | P42226 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | GMNN | O75496 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2382506 | 0.68 | CHRNB2 (0.33) | LMNANFKB1CYP2C19THPOCHRNB2 | |
| SCHEMBL15171990 | 0.67 | CHRNB2 (0.60) | LMNANFKB1CYP2C19THPONPSR1 | |
| Hydrochloric Acid SCHEMBL1701173 | 0.65 | CHRNB2 (0.58) | LMNANFKB1CYP2C19THPONPSR1 | |
| SCHEMBL5428847 | 0.64 | MAPK1 (0.42) | LMNAMAPK1NFKB1CYP2C19THPO | |
| SCHEMBL1701699 | 0.64 | LMNA (0.40) | LMNANFKB1CYP2C19THPOHIF1A | |
| SCHEMBL15114408 | 0.64 | NPSR1 (0.41) | LMNAMAPK1NFKB1CYP2C19THPO | |
| SCHEMBL28493026 | 0.62 | MAPK1 (0.52) | LMNAMAPK1NFKB1CYP2C19THPO | |
| SCHEMBL29512512 | 0.62 | MAPK1 (0.41) | LMNAMAPK1NFKB1CYP2C19THPO | |
| SCHEMBL28510511 | 0.61 | MAPK1 (0.41) | LMNAMAPK1NFKB1CYP2C19THPO | |
| SCHEMBL7700826 | 0.61 | CHRNB2 (0.32) | LMNAMAPK1NFKB1CYP2C19THPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10716770-B2 | Nicotinic receptor non-competitive antagonists | CATALYST BIOSCIENCES, INC. (US) | 2020-07-21 | — | — | US | disclosed |
| US-20190254991-A1 | Nicotinic Receptor Non-Competitive Antagonists | CATALYST BIOSCIENCES INC (US) | 2019-08-22 | — | — | US | disclosed |
| US-10258582-B2 | Nicotinic receptor non-competitive antagonists | CATALYST BIOSCIENCES, INC. (US) | 2019-04-16 | — | — | US | disclosed |
| US-20180271806-A1 | NICOTINIC RECEPTOR NON-COMPETITIVE ANTAGONISTS | CATALYST BIOSCIENCES, INC. | 2018-09-27 | — | — | US | disclosed |
| US-20170071878-A1 | NICOTINIC RECEPTOR NON-COMPETITIVE ANTAGONISTS | CATALYST BIOSCIENCES INC (US) | 2017-03-16 | — | — | US | disclosed |
| EP-2576496-B1 | NICOTINIC RECEPTOR NON-COMPETITIVE ANTAGONISTS | CATALYST BIOSCIENCES INC (US) | 2017-03-08 | — | — | EP | disclosed |
| US-9532974-B2 | Nicotinic receptor non-competitive antagonists | TARGACEPT, INC. (US) | 2017-01-03 | — | — | US | disclosed |
| US-20160008323-A1 | NICOTINIC RECEPTOR NON-COMPETITIVE ANTAGONISTS | TARGACEPT INC (US) | 2016-01-14 | — | — | US | disclosed |
| US-20140315877-A1 | NICOTINIC RECEPTOR NON-COMPETITIVE ANTAGONISTS | TARGACEPT INC (US) | 2014-10-23 | — | — | US | disclosed |
| US-8809397-B2 | Nicotinic receptor non-competitive antagonists | TARGACEPT, INC. (US) | 2014-08-19 | — | — | US | disclosed |
| US-20130203860-A1 | NICOTINIC RECEPTOR NON-COMPETITIVE ANTAGONISTS | TARGACEPT, INC. | 2013-08-08 | — | — | US | disclosed |
| EP-2576496-A1 | NICOTINIC RECEPTOR NON-COMPETITIVE ANTAGONISTS | Targacept, Inc. (US) | 2013-04-10 | — | — | EP | disclosed |
| WO-2011149859-A1 | NICOTINIC RECEPTOR NON-COMPETITIVE ANTAGONISTS | TARGACEPT, INC. (US) | 2011-12-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10258582-B2 | Nicotinic receptor non-competitive antagonists | CHRNA5, CHRNA2, CHRNG | LMNA 4132/4885MAPK1 3850/4885NFKB1 3055/4885 |
| US-20160008323-A1 | NICOTINIC RECEPTOR NON-COMPETITIVE ANTAGONISTS | CHRNA5, CHRNA2, CHRNG | LMNA 4132/4885MAPK1 3850/4885NFKB1 3055/4885 |
| US-20180271806-A1 | NICOTINIC RECEPTOR NON-COMPETITIVE ANTAGONISTS | CHRNA5, CHRNA2, CHRNG | LMNA 4132/4885MAPK1 3850/4885NFKB1 3055/4885 |
| US-20130203860-A1 | NICOTINIC RECEPTOR NON-COMPETITIVE ANTAGONISTS | CHRNA5, CHRNA2, CHRNG | LMNA 4132/4885MAPK1 3850/4885NFKB1 3055/4885 |
| US-20170071878-A1 | NICOTINIC RECEPTOR NON-COMPETITIVE ANTAGONISTS | CHRNA5, CHRNA2, CHRNG | LMNA 4132/4885MAPK1 3850/4885NFKB1 3055/4885 |
| US-10716770-B2 | Nicotinic receptor non-competitive antagonists | CHRNA5, CHRNA2, CHRNG | LMNA 4210/4885MAPK1 3832/4885NFKB1 2908/4885 |
| US-20190254991-A1 | Nicotinic Receptor Non-Competitive Antagonists | CHRNA5, CHRNA2, CHRNG | LMNA 4210/4885MAPK1 3832/4885NFKB1 2908/4885 |
| US-20140315877-A1 | NICOTINIC RECEPTOR NON-COMPETITIVE ANTAGONISTS | CHRNA5, CHRNA2, CHRNG | LMNA 4132/4885MAPK1 3850/4885NFKB1 3055/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.