Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | THPO | P40225 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | STAT6 | P42226 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | GMNN | O75496 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.41 |
| ▸ | APLNR | P35414 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19475140 | 0.79 | MAPK1 (0.33) | MAPK1NFKB1CYP2C19THPOLMNA | |
| SCHEMBL5712636 | 0.76 | HSD11B1 (0.40) | MAPK1NFKB1CYP2C19THPOLMNA | |
| SCHEMBL5940727 | 0.74 | CHRNB2 (0.32) | MAPK1NFKB1CYP2C19THPOLMNA | |
| SCHEMBL11053373 | 0.73 | MAPK1 (0.32) | MAPK1NFKB1CYP2C19THPOLMNA | |
| SCHEMBL2533774 | 0.72 | SLC1A2 (0.41) | MAPK1NFKB1CYP2C19THPOLMNA | |
| SCHEMBL14703984 | 0.71 | — | — | |
| SCHEMBL9312391 | 0.70 | LMNA (0.38) | MAPK1NFKB1CYP2C19THPOLMNA | |
| SCHEMBL9310206 | 0.70 | LMNA (0.38) | MAPK1NFKB1CYP2C19THPOLMNA | |
| SCHEMBL28851886 | 0.70 | LMNA (0.38) | MAPK1NFKB1CYP2C19THPOLMNA | |
| SCHEMBL206269 | 0.69 | CYP2C19 (0.35) | MAPK1NFKB1CYP2C19THPOLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070135445-A1 | Bicyclic Indolyl Derivatives and Methods for Their Use as Serotonergic Agents | WYETH (US) | 2007-06-14 | — | — | US | disclosed |
| US-7179813-B2 | Bicyclic indolyl derivatives and methods for their use as serotonergic agents | WYETH (US) | 2007-02-20 | — | — | US | disclosed |
| US-20060247303-A1 | 7H-dibenzo[b,g][1,5]dioxocin-5-one derivatives and use thereof | BAYER HEALTHCARE AG (DE) | 2006-11-02 | — | — | US | disclosed |
| EP-1644355-A1 | BICYCLIC INDOLYL DERIVATIVES AND METHODS OF THEIR USE AS SEROTONERGIC AGENTS | Wyeth (US) | 2006-04-12 | — | — | EP | disclosed |
| EP-1560630-A2 | 7H-DIBENZO[B,G][1,5]DIOXOCIN-5-ONE DERIVATIVES AND USE THEREOF | Bayer HealthCare AG (DE) | 2005-08-10 | — | — | EP | disclosed |
| US-20050124630-A1 | Bicyclic indolyl derivatives and methods for their use as serotonergic agents | WYETH (US) | 2005-06-09 | — | — | US | disclosed |
| WO-2004111035-A1 | BICYCLIC INDOLYL DERIVATIVES AND METHODS OF THEIR USE AS SEROTONERGIC AGENTS | WYETH (US) | 2004-12-23 | — | — | WO | disclosed |
| WO-2004039453-A2 | 7H-DIBENZO[B,G][1,5]DIOXOCIN-5-ONE DERIVATIVES AND USE THEREOF | BAYER HEALTHCARE AG (DE) | 2004-05-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135445-A1 | Bicyclic Indolyl Derivatives and Methods for Their Use as Serotonergic Agents | HTR4, HTR3A, TPH1 | MAPK1 4193/4885NFKB1 3728/4885CYP2C19 330/4885 |
| US-20050124630-A1 | Bicyclic indolyl derivatives and methods for their use as serotonergic agents | HTR4, HTR3A, TPH1 | MAPK1 4193/4885NFKB1 3728/4885CYP2C19 330/4885 |
| US-20060247303-A1 | 7H-dibenzo[b,g][1,5]dioxocin-5-one derivatives and use thereof | CETP, APOB, MTTP | MAPK1 3759/4885NFKB1 1291/4885CYP2C19 3602/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.