Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 8/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.39 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.39 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18267322 | 0.88 | MAPT (0.45) | NPC1MAPTCASP3RAB9ASMN1; SMN2 | |
| SCHEMBL1016954 | 0.86 | NPC1 (0.41) | NPC1MAPTCASP3RAB9ASMN1; SMN2 | |
| SCHEMBL1017191 | 0.85 | CYP4F2 (0.51) | NPC1MAPTCASP3RAB9ASMN1; SMN2 | |
| SCHEMBL22084670 | 0.84 | NPC1 (0.54) | NPC1MAPTCASP3RAB9ASMN1; SMN2 | |
| SCHEMBL8246361 | 0.83 | LOXL2 (0.44) | CA12CA1CA2CA9LOXL2 | |
| SCHEMBL12979162 | 0.83 | ALDH1A1 (0.41) | MAPTLOXL2NR1H2SLC7A5 | |
| SCHEMBL1827959 | 0.83 | LOXL2 (0.54) | CSNK2A1NPC1MAPTCASP3RAB9A | |
| SCHEMBL27688090 | 0.82 | NPC1 (0.41) | NPC1MAPTCASP3RAB9ASMN1; SMN2 | |
| SCHEMBL1018101 | 0.82 | SLC7A5 (0.40) | MAPTSMN1; SMN2LOXL2NR1H2NR1H4 | |
| SCHEMBL1016984 | 0.81 | CA12 (0.40) | NPC1MAPTCASP3RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9663527-B2 | Factor XIa inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-05-30 | — | — | US | disclosed |
| US-20160347757-A1 | FACTOR XIa INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-12-01 | — | — | US | disclosed |
| WO-2015123090-A1 | FACTOR XIA INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-08-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160347757-A1 | FACTOR XIa INHIBITORS | F11, SERPINC1, TFPI | CSNK2A1 2227/4885NPC1 1211/4885MAPT 3611/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.