SCHEMBL1702274

SCHEMBL1702274

COc1ccc2c(c1O)CCN2

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOTUM Q6P988 1/20 0.42
CHRNB2 P17787 1/20 0.39
CHRNA4 P43681 1/20 0.39
HTR2A P28223 1/20 0.39
HTR2C P28335 1/20 0.39
HTR2B P41595 1/20 0.39
KDM4E B2RXH2 2/20 0.38
ALDH1A1 P00352 2/20 0.38
MAPT P10636 2/20 0.38
LMNA P02545 1/20 0.38
TP53 P04637 1/20 0.38
CYP3A4 P08684 1/20 0.38
HPGD P15428 1/20 0.38
ALOX15 P16050 1/20 0.38
ALOX12 P18054 1/20 0.38
MAPK1 P28482 1/20 0.38
HSD17B10 Q99714 1/20 0.38
DRD2 P14416 2/20 0.38
DRD4 P21917 1/20 0.38
MEN1 O00255 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6643222 0.80 ALDH1A1 (0.46) NOTUMHTR2AHTR2CHTR2BKDM4E
SCHEMBL13957627 0.80 NOTUM (0.43) NOTUMHTR2AHTR2CHTR2BKDM4E
SCHEMBL7042190 0.79 ACHE (0.43) NOTUMHTR2AHTR2CHTR2BKDM4E
SCHEMBL3872558 0.79 NOTUM (0.59) NOTUMHTR2AHTR2CHTR2BKDM4E
SCHEMBL16037815 0.77 ACHE (0.64) KDM4EALDH1A1MAPTHPGDMEN1
SCHEMBL6688356 0.76 NOTUM (0.46) NOTUMALDH1A1DRD2DRD4
SCHEMBL7042089 0.75 DRD2 (0.42) NOTUMDRD2DRD4DRD1F3
SCHEMBL1701630 0.75 ACHE (0.56) NOTUMDRD2DRD4
SCHEMBL927341 0.74 HSD11B1 (0.41) NOTUMDRD2
SCHEMBL31158955 0.74 HSD11B1 (0.41) NOTUMDRD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 117 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2582351-B1 HAIR DYEING PROCESS USING A COMPOSITION COMPRISING AT LEAST ONE INDOLE OR INDOLINE COMPOUND, A METAL SALT, HYDROGEN PEROXIDE AND A BASIFYING AGENT L'ORÉAL (FR) 2017-08-02 EP claimed
EP-2623093-B1 DYE FOR KERATIN FIBERS USING BILIRUBIN OXIDASE AND INDOLE DERIVATIVES AMANO ENZYME INC (JP) 2016-05-25 EP claimed
US-20140359950-A1 DYEING OF KERATIN FIBERS USING INDOLE ANALOGUE AMANO ENZYME INC. (JP) 2014-12-11 US claimed
US-8597373-B2 Hair dyeing process using a composition comprising at least one indole or indoline compound, a metal salt, hydrogen peroxide and a basifying agent L'OREAL (FR) 2013-12-03 US claimed
US-20130174864-A1 HAIR DYEING PROCESS USING A COMPOSITION COMPRISING AT LEAST ONE INDOLE OR INDOLINE COMPOUND, A METAL SALT, HYDROGEN PEROXIDE AND A BASIFYING AGENT L'OREAL (FR) 2013-07-11 US claimed
EP-2582351-A1 HAIR DYEING PROCESS USING A COMPOSITION COMPRISING AT LEAST ONE INDOLE OR INDOLINE COMPOUND, A METAL SALT, HYDROGEN PEROXIDE AND A BASIFYING AGENT L'Oréal (FR) 2013-04-24 EP claimed
WO-2011157668-A1 HAIR DYEING PROCESS USING A COMPOSITION COMPRISING AT LEAST ONE INDOLE OR INDOLINE COMPOUND, A METAL SALT, HYDROGEN PEROXIDE AND A BASIFYING AGENT L'OREAL (FR) 2011-12-22 WO claimed
EP-0645999-B2 METHOD FOR DYEING KERATIN FIBRES WITH INDOLE OR INDOLIN DERIVATIVES, HYDROGEN PEROXIDE AND A PEROXIDASE OREAL (FR) 2006-09-27 EP claimed
EP-0575604-B2 INDOLINE PRODUCTS, METHODS FOR PREPARING SAME, AND USE THEREOF IN COSMETICS OREAL (FR) 2003-03-26 EP claimed
US-5776497-A OXIDATIVE POLYMERIZATION OF INDOLINE FOR COSMETICS L'OREAL (FR) 1998-07-07 US claimed
EP-0645999-B1 METHOD FOR DYEING KERATIN FIBRES WITH INDOLE OR INDOLIN DERIVATIVES, HYDROGEN PEROXIDE AND A PEROXIDASE OREAL (FR) 1996-01-31 EP claimed
EP-0575604-B1 INDOLINE PRODUCTS, METHODS FOR PREPARING SAME, AND USE THEREOF IN COSMETICS OREAL (FR) 1995-12-06 EP claimed
EP-0603322-A1 DYEING COMPOSITION BASED ON HYDROXYINDOLINE DERIVATIVES. OREAL (FR) 1994-06-29 EP claimed
EP-0575604-A1 INDOLINE PRODUCTS, METHODS FOR PREPARING SAME, AND USE THEREOF IN COSMETICS. OREAL (FR) 1993-12-29 EP claimed
EP-0575605-A1 MINERAL OR ORGANIC PARTICLE BASED PRODUCT COMPRISING AN INDOLINE PRODUCT. OREAL (FR) 1993-12-29 EP claimed
WO-1993013744-A1 INDOLINE PRODUCTS, METHODS FOR PREPARING SAME, AND USE THEREOF IN COSMETICS L'OREAL (FR) 1993-07-22 WO claimed
WO-1993013745-A1 MINERAL OR ORGANIC PARTICLE BASED PRODUCT COMPRISING AN INDOLINE PRODUCT L'OREAL (FR) 1993-07-22 WO claimed
EP-0544874-A1 METHOD FOR PREPARING SUBMICRON PARTICLES IN THE PRESENCE OF LIPID VESICLES, AND CORRESPONDING COMPOSITIONS L'OREAL (FR) 1993-06-09 EP claimed
WO-1993005018-A1 DYEING COMPOSITION BASED ON HYDROXYINDOLINE DERIVATIVES L'OREAL (FR) 1993-03-18 WO claimed
WO-1993000068-A1 METHOD FOR PREPARING SUBMICRON PARTICLES IN THE PRESENCE OF LIPID VESICLES, AND CORRESPONDING COMPOSITIONS L'OREAL (FR) 1993-01-07 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130174864-A1 HAIR DYEING PROCESS USING A COMPOSITION COMPRISING AT LEAST ONE INDOLE OR INDOLINE COMPOUND, A METAL SALT, HYDROGEN PEROXIDE AND A BASIFYING AGENT KRT18, HCN4, IDO1 NOTUM 2216/4885CHRNB2 955/4885CHRNA4 759/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.