Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.42 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | WNT3A | P56704 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | MELK | Q14680 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17023015 | 0.86 | L3MBTL1 (0.54) | L3MBTL1RAB9ASMN1; SMN2FGFR3PDE7A | |
| SCHEMBL1126611 | 0.85 | L3MBTL1 (0.60) | L3MBTL1RAB9ASMN1; SMN2FGFR3PDE7A | |
| SCHEMBL17023016 | 0.84 | FGFR3 (0.49) | L3MBTL1RAB9ASMN1; SMN2FGFR3PDE7A | |
| SCHEMBL17023125 | 0.82 | L3MBTL1 (0.47) | L3MBTL1RAB9ASMN1; SMN2FGFR3PPARG | |
| SCHEMBL17023034 | 0.81 | FGFR3 (0.49) | L3MBTL1RAB9ASMN1; SMN2FGFR3PPARG | |
| SCHEMBL17023075 | 0.77 | FGFR3 (0.54) | FGFR3 | |
| SCHEMBL4321851 | 0.75 | L3MBTL1 (0.39) | L3MBTL1RAB9ASMN1; SMN2FGFR3KDM4E | |
| SCHEMBL17023121 | 0.74 | FGFR3 (0.40) | FGFR3MAPTKDM4EALDH1A1KMT2A | |
| SCHEMBL29739477 | 0.72 | GAA (0.68) | L3MBTL1RAB9ASMN1; SMN2PPARGEGFR | |
| SCHEMBL1126163 | 0.72 | L3MBTL1 (0.67) | L3MBTL1RAB9ASMN1; SMN2FGFR3PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2282995-B1 | DERIVATIVES OF QUINOLINES AND QUINOXALINES AS PROTEIN TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2015-08-26 | — | — | EP | claimed |